Bidirectional Modulation of Extinction of Drug Seeking by Deep Brain Stimulation of the Ventral Striatum

Martínez-Rivera, Freddyson J.; Rodríguez-Romaguera, Jose; Lloret-Torres, Mario E.; Monte, Fabricio H Do; Quirk, Gregory J.; Barreto-Estrada, Jennifer L.

doi:10.1016/j.biopsych.2016.05.015

Cited by 53 publications

(43 citation statements)

References 67 publications

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“…c-Fos immunohistochemistry (IHC) was performed as previously described (Bravo-Rivera et al 2014; Martinez-Rivera et al 2016) with some modifications. One hour after the end of the behavioral test, rats were anesthetized with sodium pentobarbital (450 mg/kg, i.p.)…”

Section: Methodsmentioning

confidence: 99%

Prefrontal circuits signaling active avoidance retrieval and extinction

et al. 2018

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Objective Neurons in PL and IL project densely to two areas implicated in active avoidance: the basolateral amygdala (BLA) and the ventral striatum (VS). We therefore combined c-Fos immunohistochemistry with retrograde tracers to characterize signaling in platform-mediated active avoidance. Methods Male rats were infused with retrograde tracers (CTB, FB) into basolateral amygdala and ventral striatum and conditioned to avoid tone-signaled footshocks by stepping onto a nearby platform. In a subsequent test session, rats received either 2 unreinforced tones (avoidance retrieval) or 15 unreinforced tones (avoidance extinction) followed by analysis of c-Fos combined with fluorescent imaging of retrograde tracers. Results Retrieval of avoidance did not activate IL neurons, but did activate PL neurons projecting to BLA, and to a lesser extent VS. Extinction of avoidance activated IL neurons projecting to both BLA and VS, as well as PL neurons projecting to VS. Conclusions Our observation that avoidance retrieval is signaled by PL projections to BLA suggests that PL may modulate VS indirectly via BLA, and agrees with other findings implicating BLA in active avoidance. Less expected was the signaling of extinction via PL inputs to VS, which may converge with IL inputs to VS to inhibit expression of avoidance.

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Section: Methodsmentioning

confidence: 99%

Prefrontal circuits signaling active avoidance retrieval and extinction

et al. 2018

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“…Reversible pharmacological inactivation of the ventromedial, but not dorsomedial, AcbSh causes reinstatement of alcohol seeking (Millan et al ., ). Finally, high‐frequency electrical stimulation of a region extending from the AcbC to dorsomedial AcbSh, but not one that encompasses ventromedial AcbSh, impairs extinction of a morphine conditioned place preference (Martínez‐Rivera et al ., ). Although these three findings are difficult to reconcile with each other as well as with a simple appetitive—aversive gradient across dorsomedial to ventromedial AcbSh, they highlight the importance of understanding the different roles of these AcbSh subdivisions in reinstatement vs. extinction and in learning and behavior more broadly.…”

Section: Linking Dual Roles In Extinction and Reinstatement To Heteromentioning

confidence: 97%

The nucleus accumbens shell in reinstatement and extinction of drug seeking

Gibson

Millan

McNally

2018

Eur J of Neuroscience

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The contexts where drugs are self-administered have important control over relapse and extinction of drug-seeking behavior. The nucleus accumbens shell (AcbSh) is essential to this contextual control over drug-seeking behavior. It has been consistently implicated in both the expression of context-induced reinstatement and the expression of extinction, across a variety of drug classes and other rewards. Here, we review the evidence linking AcbSh to the extinction and reinstatement of drug seeking. We consider whether this dual role can be linked to known heterogeneities in AcbSh cell types, their major afferents, and their major efferents. We show that although these heterogeneities are each important and can determine extinction vs. reinstatement, they do not seem adequate to explain the body of findings from the behavioral literature. Rather, we suggest that this functional specialization of AcbSh may be more profitably viewed in terms of the segregation and compartmentalization of AcbSh channels.

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“…In conclusion, studies like that by Martínez-Rivera et al (4) are important as they attempt to disentangle the role of specific frequencies and neural circuits underlying behavioral effects. By using circuit dissection approaches in pre-clinical models, it is possible to reverse-engineer effective therapies to understand underlying mechanisms.…”

mentioning

confidence: 94%

“…Martínez-Rivera et al (4), apply and compare two stimulation frequencies, namely 100 Hz (high) and 20 Hz (lower, beta-frequency) DBS to the ventral striatum in a morphine conditioned place preference (CPP) paradigm. They demonstrate that beta-frequency can enhance extinction of morphine-induced drug memories, through activation of this reward circuitry.…”

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confidence: 99%