This paper presents an optical communication system, implementing a UWB-inspired pulsed coding technique, for emerging high throughput bio-applications such as brain machine interfaces. The proposed solution employs sub-nanosecond laser pulses that, compared to the state-of-the-art, allows for high bit rate transmissions and reduced power consumption. The overall architecture consist of a transmitter and receiver that employ a pulsed semiconductor laser and a small sensitive area photodiode. This can allow for CMOS integration into a compact silicon footprint (estimated lower than 1 mm 2 in a 0.18 µm technology). The analogue circuits presented herein have been implemented using discrete off-the-shelf components. These provide the bias and drive signals for laser pulse generation, photodiode signal detection and conditioning. Moreover, the digital subsystem for data coding and decoding processes have been implemented on a FPGA board through VHDL description language. Experimental results validate the overall functionality of the proposed system using a diffuser between transmitter and receiver to emulate skin/tissue. This shows the capability of operating at bit rates up to 250 Mbps achieving BER less than 10 −9 and power efficiency as low as 24 pJ/bit. These results enable, for example, the transmission of a 1000-channel neural recording system sampled at 16kHz with 16-bit resolution.