1997
DOI: 10.1002/(sici)1097-0169(1997)38:3<229::aid-cm2>3.0.co;2-0
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Bidirectional pigment granule migration in isolated retinal pigment epithelial cells requires actin but not microtubules

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Cited by 29 publications
(64 citation statements)
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“…This notion is confirmed by studies on melanophores, where bidirectional long-range pigment motility depends on a Kinesin-2 and dynein, whereas F-actin and Myosin-V are involved in short-range dispersal, apical tethering, and fine tuning of MT-based motility (reviewed in Brown, 1999). However, there are exceptions to this rule, because long-distance pigment granule traffic in retinal pigment epithelial cells is F-actin dependent (King-Smith et al, 1997). However, there are exceptions to this rule, because long-distance pigment granule traffic in retinal pigment epithelial cells is F-actin dependent (King-Smith et al, 1997).…”
Section: Introductionmentioning
confidence: 80%
“…This notion is confirmed by studies on melanophores, where bidirectional long-range pigment motility depends on a Kinesin-2 and dynein, whereas F-actin and Myosin-V are involved in short-range dispersal, apical tethering, and fine tuning of MT-based motility (reviewed in Brown, 1999). However, there are exceptions to this rule, because long-distance pigment granule traffic in retinal pigment epithelial cells is F-actin dependent (King-Smith et al, 1997). However, there are exceptions to this rule, because long-distance pigment granule traffic in retinal pigment epithelial cells is F-actin dependent (King-Smith et al, 1997).…”
Section: Introductionmentioning
confidence: 80%
“…In addition to the initial association of the melanosome with the apical actin cytoskeleton and/or movement through it, Rab27a/myosin VIIa may play a role in the subsequent movement within the apical processes. Melanosome movement along apical processes has been most extensively studied in teleost RPE, where both dispersion to the tips and aggregation within the cell body are dependent on actin filaments because they are disrupted upon cytochalasin treatment (King-Smith et al, 1997). Aggregation but not dispersion may also have a requirement for microtubules (Troutt and Burnside, 1989).…”
Section: How Does Rab27a Regulate Melanosome Movement Within the Rpe?mentioning
confidence: 99%
“…In the RPE of fi sh, both microtubules and actin fi laments, the cytoskeletal tracks for organelle motility, are present in apical projections, and both contribute to melanosome motility. Rather, disruption of actin fi laments blocked both pigment granule aggregation and dispersion (King-Smith et al, 1997 ). However, in dissociated RPE cells cultured in vitro , depolymerization of microtubules had no effect on pigment granule movement through apical projections.…”
Section: Introductionmentioning
confidence: 88%
“…RPE cells were isolated as described previously (King-Smith et al, 1997 ;King-Smith, 2009 ). Fish were dark adapted for at least 30 min and anesthetized in 75 mg/L MS-222 (Tricaine, Sigma-Aldrich, St. Louis, MO).…”
Section: Rpe Cell Isolationmentioning
confidence: 99%
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