Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer—preventive actions of dietary factors

Su, Ying; Shankar, Kartik; Rahal, Omar; Simmen, Rosalia C. M.

doi:10.1016/j.jnutbio.2010.09.008

Cited by 17 publications

(17 citation statements)

References 107 publications

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“…Breast cancer originates from subversions of normal growth regulatory pathways in mammary epithelial cells, due to genetic mutations and epigenetic modifications in tumor suppressors, oncogenes and DNA repair genes (Badve et al, 2011, Su et al, 2011. Breast cancer subtyping (luminal, basal) has been defined by patterns of gene expression that reflect these lineages (Sorlie et al, 2003).…”

Section: Normal Mammary Gland Development and Tumorigenesismentioning

confidence: 99%

“…The stromal environment contributes to a vascular bed, an immunomodulation, a lymphatic drainage, a unique adipose-rich fat pad and an extracellular matrix-rich microenvironment, elements acting in concert to maintain the mammary epithelial 'niche' and reveal the complex endocrine function of adipose tissue. Related extracellular signals derive from the endocrine milieu and the stroma, facilitating a dynamic paracrine regulation, as well as the integration of signals from circulating hormones, cytokines and growth factors (Su et al, 2011).…”

Section: Cross-talk Mechanisms Between Er and Signal Transduction Undmentioning

confidence: 99%

“…Prospect that diet associated components may equally influence mammary stromal biology with regard to the course of differentiation or neoplastic growth of epithelium has not been widely addressed (Su et al, 2011), although its fate and ductal development are both controlled to a large extent by mammary fibroblastic and adipocyte mesenchyme. Hence, given the emerging evidence for dietary products to breast cancer risk, high consumption is not a reasonable or advisable attitude, even if some beneficial attitude may be expected.…”

Section: Effects Of Isoflavone-rich Foodsmentioning

confidence: 99%

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Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis

Pelekanou¹,

Leclercq²

2011

Int. J. Dev. Biol.

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The present �or� revie�s recent � ndings related to the action of steroidal �physiolo�The present �or� revie�s recent �ndings related to the action of steroidal �physiolo� gical) estrogens on normal mammary gland development and carcinogenesis, as �ell as effects of related environmental mediators �phyto� and xeno�estrogens), the role of �hich remains controver� sial. Orchestration by estrogen receptors �i.e. ERa and ERb) and coregulators of gro�th, apoptosis and differentiation of epithelial cells, directed our analysis. The bidirectional coordination bet�een epithelium and stroma in parallel �ith maintenance of stemness are also investigated. The rele� vance of nuclear and extranuclear localization of ERs and other eventual estrogen binding sites, mediating differential actions in regard to these various topics, is critically addressed to delineate the importance of direct and indirect activation procedures and delicate feedbac� loops �ligand� induced or/and cross�tal� activation, respectively). The inclusion of the outlined regulatory concepts in drug design programs for the prevention and treatment of breast cancer may have potent effects.

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Section: Normal Mammary Gland Development and Tumorigenesismentioning

confidence: 99%

Section: Cross-talk Mechanisms Between Er and Signal Transduction Undmentioning

confidence: 99%

Section: Effects Of Isoflavone-rich Foodsmentioning

confidence: 99%

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Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis

Pelekanou¹,

Leclercq²

2011

Int. J. Dev. Biol.

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“…Retained nipples in male rats treated with V have suggested that androgens may play an important role in early sex differentiation of the mammary gland (Gray et al 1994. Cooperation of signaling pathways between epithelium and mesenchyme in embryonic or in the postnatal mammary gland development have been addressed in several reviews (Robinson 2007, Su et al 2011. The AR is abundantly expressed in normal mammary epithelium, but not detected in mammary stroma or myoepithelium (Somboonporn & Davis (2004) and data not shown).…”

Section: Mechanisms Underlying the Effects Of Vmentioning

confidence: 98%

In utero and lactational exposure to vinclozolin and genistein induces genomic changes in the rat mammary gland

Saad

Toullec

Vacher

et al. 2012

Journal of Endocrinology

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Exposure to low doses of environmental estrogens such as bisphenol A and genistein (G) alters mammary gland development. The effects of environmental anti-androgens, such as the fungicide vinclozolin (V), on mammary gland morphogenesis are unknown. We previously reported that perinatal exposure to G, V, and the GV combination causes histological changes in the mammary gland during the peripubertal period, suggesting alterations to the peripubertal hormone response. We now investigate whether perinatal exposure to these compounds alters the gene expression profiles of the developing glands to identify the dysregulated signaling pathways and the underlying mechanisms. G, V, or GV (1 mg/kg body weight per day) was added to diet of Wistar rats, from conception to weaning; female offspring mammary glands were collected at postnatal days (PNDs) 35 and 50. Genes displaying differential expression and belonging to different functional categories were validated by quantitative PCR and immunocytochemistry. At PND35, G had little effect; the slight changes noted were in genes related to morphogenesis. The changes following exposure to V concerned the functional categories associated with development (Cldn1, Krt17, and Sprr1a), carbohydrate metabolism, and steroidogenesis. The GV mixture upregulated genes (Krt17, Pvalb, and Tnni2) involved in muscle development, indicating effects on myoepithelial cells during mammary gland morphogenesis. Importantly, at PND50, cycling females exposed to GV showed an increase in the expression of genes (Csn2, Wap, and Elf5) related to differentiation, consistent with the previously reported abnormal lobuloalveolar development previously described. Thus, perinatal exposure to GV alters the mammary gland hormone response differently at PND35 (puberty) and in animals with established cycles.

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“…A highly dynamic epithelium and the underlying stroma, the two main cellular compartments, comprise the mammary gland (Su et al, 2011). Once breast cancer initiates due to genetic mutations and epigenetic modifications on oncogenes, DNA repair genes and tumor suppressors, the normal growth regulatory pathways are altered in mammary epithelial cells (Su et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Systematically identify key genes in inflammatory and non-inflammatory breast cancer

Chai

Liang

Zhang

et al. 2016

Gene

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Bidirectional signaling of mammary epithelium and stroma: implications for breast cancer—preventive actions of dietary factors

Cited by 17 publications

References 107 publications

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis

Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis

In utero and lactational exposure to vinclozolin and genistein induces genomic changes in the rat mammary gland

Systematically identify key genes in inflammatory and non-inflammatory breast cancer

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