2021
DOI: 10.7554/elife.73046
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Bidirectional synaptic plasticity rapidly modifies hippocampal representations

Abstract: Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic calcium spikes, or plateau potentials, has been reported to underlie place field formation in rodent hippocampal CA1 neurons. Here we found that this behavioral timescale synaptic plasticity (BTSP) can also reshape existing place fields via bidirectional synaptic weight changes that depend on the temporal proximity of plateau potentials… Show more

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Cited by 91 publications
(155 citation statements)
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References 111 publications
(159 reference statements)
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“…Next we questioned whether a recently discovered synaptic plasticity type, BTSP 12 , 13 , could underlie the experience-dependent formation of the CA1 representation on day 1. BTSP is exclusively driven by long-duration dendritic voltage signals, Ca 2+ plateau potentials (‘plateaus’), that can induce plasticity in a single trial 14 18 (Fig.…”
Section: Role Of Btspmentioning
confidence: 99%
See 1 more Smart Citation
“…Next we questioned whether a recently discovered synaptic plasticity type, BTSP 12 , 13 , could underlie the experience-dependent formation of the CA1 representation on day 1. BTSP is exclusively driven by long-duration dendritic voltage signals, Ca 2+ plateau potentials (‘plateaus’), that can induce plasticity in a single trial 14 18 (Fig.…”
Section: Role Of Btspmentioning
confidence: 99%
“…Together, these results indicate that the EC3 provides a relatively invariant instructive signal that is more reminiscent of a target signal than an error signal. In our current scheme, the excitatory target from EC3 combines in the apical dendrites with an inhibitory signal representing the actual CA1 population activity, and the resulting plateau potentials function as a local error signal that is unique in each CA1 neuron 13 , 37 , 38 (Fig. 6c,d ).…”
Section: Form Of Ec3 Instructive Signalmentioning
confidence: 99%
“…A key common variable in the different models is the relationship between excitation and inhibition within and outside the place field, which has been the subject of intense debate, due mainly to the paucity of observational data ( Grienberger et al, 2017 ; Harvey et al, 2009 ; Lapray et al, 2012 ; Royer et al, 2012 ). Perisomatic inhibitory drive within the place field has been proposed to increase ( Bhatia et al, 2019 ; Milstein et al, 2021 ), remain unchanged ( Grienberger et al, 2017 ), or decrease ( Geiller et al, 2022 ; Valero et al, 2022 ) inside the place field ( Figure 1B ). Yet, how competition between excitatory and inhibitory conductances contributes to the fundamental properties of place cells has remained largely unexplained ( Figure 1C ).…”
Section: Introductionmentioning
confidence: 99%
“… Rolotti et al (2022) showed such disinhibition can improve performance on a head-fixed spatial goal-oriented learning task via overrepresentation of the rewarded locations used for performance in the task. Another functional benefit of such disinhibition may be in rapid place field formation, as is seen in the behavioral timescale synaptic plasticity mechanism ( Bittner et al, 2017 ; Zhao et al, 2020 ; Milstein et al, 2021 ). Our modeling results suggest similar effects may be possible without the use of disinhibition but rather simply via a rebalancing of the relative activity or strength between different inhibitory populations.…”
Section: Discussionmentioning
confidence: 99%