Bidirectional thermo-regulating hydrogel composite for autonomic thermal homeostasis

Park, Gyeongsuk; Park, Hyunmin; Seo, Jae M.; Yang, Jun; Kim, Min; Lee, Bong Jae; Park, Steve

doi:10.1038/s41467-023-38779-w

“…sive, acrylamide hydrogel microstructures are capable of mechanical distortion with temperature fluctuation. [113] Therefore, this system was employed to showcase homeostatic behavior by integrating a series of complete, continuous feedback loops, such as C!M!C!M! • • • or C* * M, and thereby keeping the temperature of the system in a narrow range (Figures 14F, G).…”

Section: Kurzaufsätzementioning

confidence: 99%

Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises

Ranganath,

Maity

2024

Angewandte Chemie

0

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Feedback‐controlled chemical reaction networks (FCRNs) are indispensable for various biological processes, such as cellular mechanisms, patterns, and signaling pathways. Through the intricate interplay of many feedback loops (FLs), FCRNs maintain a stable internal cellular environment. Currently, creating minimalistic synthetic cells is the long‐term objective of systems chemistry, which is motivated by such natural integrity. The design, kinetic optimization, and analysis of FCRNs to exhibit functions akin to those of a cell still pose significant challenges. Indeed, reaching synthetic homeostasis is essential for engineering synthetic cell components. However, maintaining homeostasis in artificial systems against various agitations is a difficult task. Several biological events can provide us with guidelines for a conceptual understanding of homeostasis, which can be further applicable in designing artificial synthetic systems. In this regard, we organize our review with artificial homeostasis systems driven by FCRNs at different length scales, including homogenous, compartmentalized, and soft material systems. First, we stretch a quick overview of FCRNs in different molecular and supramolecular systems, which are the essential toolbox for engineering different nonlinear functions and homeostatic systems. Moreover, the existing history of synthetic homeostasis in chemical and material systems and their advanced functions with self‐correcting, and regulating properties are also emphasized.

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“…The material motion by the chemo‐mechano‐chemical cycle triggered robotic function driven by chemical reaction resulting acid/base exchange or catalytic reactions generating oxygen bubbles through H 2 O 2 decomposition (Figures 14A–E). Especially being thermoresponsive, acrylamide hydrogel microstructures are capable of mechanical distortion with temperature fluctuation [113] . Therefore, this system was employed to showcase homeostatic behavior by integrating a series of complete, continuous feedback loops, such as C→M→C→M→ ⋅ ⋅ ⋅ or C⇌M, and thereby keeping the temperature of the system in a narrow range (Figures 14F, G).…”

Section: Homeostasis In Synthetic Chemical and Materials Systemsmentioning

confidence: 99%

Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises

Ranganath,

Maity

2024

Angew Chem Int Ed

8

0

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Feedback‐controlled chemical reaction networks (FCRNs) are indispensable for various biological processes, such as cellular mechanisms, patterns, and signaling pathways. Through the intricate interplay of many feedback loops (FLs), FCRNs maintain a stable internal cellular environment. Currently, creating minimalistic synthetic cells is the long‐term objective of systems chemistry, which is motivated by such natural integrity. The design, kinetic optimization, and analysis of FCRNs to exhibit functions akin to those of a cell still pose significant challenges. Indeed, reaching synthetic homeostasis is essential for engineering synthetic cell components. However, maintaining homeostasis in artificial systems against various agitations is a difficult task. Several biological events can provide us with guidelines for a conceptual understanding of homeostasis, which can be further applicable in designing artificial synthetic systems. In this regard, we organize our review with artificial homeostasis systems driven by FCRNs at different length scales, including homogenous, compartmentalized, and soft material systems. First, we stretch a quick overview of FCRNs in different molecular and supramolecular systems, which are the essential toolbox for engineering different nonlinear functions and homeostatic systems. Moreover, the existing history of synthetic homeostasis in chemical and material systems and their advanced functions with self‐correcting, and regulating properties are also emphasized.

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Cation‐Alginate Complexes and Their Hydrogels: A Powerful Toolkit for the Development of Next‐Generation Sustainable Functional Materials

Tordi,

Ridi,

Samorì

et al. 2024

Adv Funct Materials

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The use of materials from renewable sources instead of fossil fuels is a crucial step forward in the industrial transition toward sustainability. Among polysaccharides, alginate stands out as a versatile and eco‐friendly candidate due to its ability to form functional complexes with cations. This review provides an up‐to‐date and comprehensive description of alginate complexation with specific cations, focusing on how interaction forces can be harnessed to tailor the physicochemical properties of cation‐alginate‐based functional materials. Methodologies and approaches for the development and multiscale characterization of these materials are introduced and discussed. Alginate complexes with mono‐, di‐, tri‐, and tetravalent cations (namely Ag+, Mg2+, Ca2+, Sr2+, Ba2+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Pb2+, UO22+, Cr3+, Fe3+, Al3+, Ga3+, Y3+, La3+, Ce3+, Nd3+, Eu3+, Tb3+, Gd3+, Zr4+, Th4+) are reviewed. Each cation is discussed individually, highlighting how it can uniquely influence the material properties thereby unlocking new potentials for the design of advanced functional materials. Key challenges and opportunities in applying these complexes across diverse fields, such as biomedicine, environmental remediation, food additives and supplements, flame retardants, sensors, supercapacitors, catalysis, and mechanical isolators are assessed, providing evidence of the transformative potential of cation‐alginate complexes for tackling global challenges and advancing cutting‐edge technologies.

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Bidirectional thermo-regulating hydrogel composite for autonomic thermal homeostasis

Cited by 9 publications

References 38 publications

Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises

Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises

Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises

Cation‐Alginate Complexes and Their Hydrogels: A Powerful Toolkit for the Development of Next‐Generation Sustainable Functional Materials

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