Biebsanin — A new susquiterpene lactone fromAchillea biebersteinii andA. santolina

Highly Unsaturated Isopentyl Amides from Achillea wilhelmsii

“…In Egypt and in some Mediterranean countries the plant is used for stomach ailments and digestive disorders (6). Previous papers on this species have been concerned with sesquiterpene lactones (7)(8)(9)(10) and polyacetylenes (11), whereas a more recent article has described the different essential oil compositions of a Turkish and of an Egyptian provenance (6). The present study on the underground parts reveals a series of 13 new alkamides whose structures were elucidated by spectroscopic methods.…”

“…Following the arguments outlined above, 'H-nmr and ms evidence indicated the proposed structures. C]4~Alkamides 8-13--The isopentyl amides 8 and 9 differ only by the 6Z- [8] or 6£-double bond [9] in the completely conjugated acid moiety. Highly unsaturated, polyacetylenic compounds are very sensitive to light-induced polymerization leading to blue insoluble products [Bohlmann etal.…”

A new sesquiterpene lactone and seco guaianolides from Achillea cretica L. growing in Tunisia

“…It should also be noted that related chlorohydrin guaianolides were isolated previously from only a few Achillea species, such as Achillea biebersteinii and Achillea santolina (Yusupov et al, 1979), Achillea clusiana (Todorova et al, 1999), Achillea depressa (Trifunovic et al, 2005), A. chillea ligustica (Ahmed et al, 2003) as well as Achillea clavennae (Trifunovic et al, 2006). Lactone 1 exhibited the same molecular formula (C 15 H 19 O 5 Cl) and the overall appearance of the 1 H NMR spectrum (Table 2), very similar to that of as the known guaianolide andalucin (Aguilar et al, 1988;Trifunovic et al, 2006).…”

In vitro Apoptotic effects of the medicinal plants Achillea santolina and Raphanus sativus extracts on different cancer cell lines

“…As such the antitumor effect of medicinal plants with different active A. santolina is a flowering wild plant from family Asteraceae, which is distributed particularly in the northern hemisphere (Khan, 1998;Si et al, 2006;Ebadi, 2006). The aerial parts of A. santolina contain volatile oils (Bader et al, 2003;El-Shazly et al, 2004), flavonoids and sesquiterpene lactone (Yusopov et al, 1979). Moreover, this species produces alkaloids, saponins, tannins, resins, sterols, carbohydrates, which have anti-inflammatory effects (Al-Snafi, 2013).…”