Human skeletal and dental remains are the primary focus of bioarchaeological research, as different diseases and pathological conditions can leave marks on the bones and teeth. Study of these remains provides insights into the lifestyle, health and quality of life of past populations. In this paper, the human skeletal remains from the Ozad Arene archaeological site in Pula (Istria, Croatia), originating from 25 graves and four bone assemblages dated between the 1st and the 4th centuries CE, were analysed. The aim of the paper is to reconstruct demographic and pathological characteristics of the Roman period population from Pula to gain insight into the living conditions and the quality of life in this community, and to determine whether the site differs from other archaeological sites from the same period in terms of general health and living conditions. The human skeletal sample in question comprises skeletal remains of a minimum 48 individuals; the high subadult mortality rate and high prevalence of dental enamel hypoplasia and the presence of cribra orbitalia, porotic hyperostosis, and periostitis indicate overall poor living conditions and widespread metabolic stress during childhood in Pula. Vertebral osteoarthritis and Schmorl′s nodes in the spines of younger individuals suggest continuous hard labour and strenuous physical activity. Based on the available data, it seems that living conditions in the Roman period Pula did not differ significantly from other Roman sites on the eastern Adriatic coast.