The study was on the identification of hazards in the production of "ogiri" from creeping melon (Citrullus vulgaris), climbing melon (Cucumeropsis manii), castor oil (Ricinus communis) and fluted pumpkin (Telfairia occidentalis) seeds and establishment of Critical Control Points in the course of production. The processed and unprocessed samples as well as utensils, packaging materials and water used in the production of "ogiri" were analyzed using standard methods. Hazard analysis was carried out at each stage of production. Samples were collected from different States in Nigeria.Microbial isolates were obtained from different sources (raw seeds, processed "ogiri", handlers, utensils, packaging materials as well as each stage of production. The bacterial and fungal isolates were identified by DNA sequencing 165rDNA and ITSrDNA. The Critical Control Points were determined using decision tree and the results analyzed statistically using Analysis of Variance (ANOVA). The mean viable microbial counts of raw and processed samples significantly (P<0.05) increased from 8.3 x 10 4 to 3.7 x 10 8 cfu/g, 9.5 x 10 4 to 5.2 x 10 8 cfu/g, 9.8 x 10 4 to 4.7 x 10 8 cfu/g and 7.6 x 10 4 to 4.5 x 10 8 cfu/g in climbing melon, castor oil, creeping melon and fluted pumpkin respectively. The coliform counts from different sources were higher than the acceptable limits 10 4 cfu/g and 10 2 cfu/g for heterotrophic bacteria and coliform respectively. The heavy metal contents were higher in the raw than in the processed samples. The hazard analysis revealed sorting, washing,