Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model

Reichold, A.; Brenner, Sibylle; Spruss, Astrid; Förster-Fromme, Karin; Bergheim, Ina; Bischoff, Stephan C.

doi:10.1016/j.jnutbio.2013.09.011

Cited by 66 publications

(45 citation statements)

References 45 publications

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“…Applying these different diets, we were able to show that both diets rich in fat and fructose add to the development of liver steatosis over time; however, a combined feeding of these two macronutrients was found to exacerbate the damaging effect of each macronutrient by itself. Somewhat contrary to the studies of others feeding high-fat, high-fructose or so-called Western-style diets [19,[23][24][25][26], in the present study, none of the feeding groups reached the full stage of NASH or even developed early fibrosis. Reasons for this might be related to the fact that mice were kept under SOPF conditions in the present study, whereas in most other studies, feeding experiments were conducted in standard pathogen-free facilities implying that intestinal microbiota was markedly different.…”

Section: Discussioncontrasting

confidence: 99%

“…These data suggest that mice fed the diet enriched in fat and fructose changed their energy expenditure, decreased their physical activity or more efficiently metabolized consumed energy. Others feeding a so-called Western-style diet being rich in fat, sucrose and cholesterol or diets rich in high-fructose corn syrup in combination with a high-fat diet also report that mice fed these diets develop obesity after 6-8 weeks of feeding [20,24,26]; however, mechanisms involved in the massive weight gain remain to be determined. Taken together, our data suggest that, in mice, chronic intake of a diet rich in fat or fructose leads to the development of hepatic steatosis, which progresses with time and is most pronounced when both macronutrients are combined.…”

Section: Discussionmentioning

confidence: 99%

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Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time

Sellmann

Priebs

Landmann

et al. 2015

The Journal of Nutritional Biochemistry

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111

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time

Sellmann

Priebs

Landmann

et al. 2015

The Journal of Nutritional Biochemistry

Self Cite

149

111

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“…S1 in the supplemental material). The established metabolic benefits of the species B. adolescentis serve as another rationale for the selection of IVS-1 for future applications (39,40).…”

Section: Resultsmentioning

confidence: 99%

In Vivo Selection To Identify Bacterial Strains with Enhanced Ecological Performance in Synbiotic Applications

Krumbeck

Maldonado-Gómez

Martínez

et al. 2015

Appl Environ Microbiol

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One strategy for enhancing the establishment of probiotic bacteria in the human intestinal tract is via the parallel administration of a prebiotic, which is referred to as a synbiotic. Here we present a novel method that allows a rational selection of putative probiotic strains to be used in synbiotic applications: in vivo selection (IVS). This method consists of isolating candidate probiotic strains from fecal samples following enrichment with the respective prebiotic. To test the potential of IVS, we isolated bifidobacteria from human subjects who consumed increasing doses of galactooligosaccharides (GOS) for 9 weeks. A retrospective analysis of the fecal microbiota of one subject revealed an 8-fold enrichment in Bifidobacterium adolescentis strain IVS-1 during GOS administration. The functionality of GOS to support the establishment of IVS-1 in the gastrointestinal tract was then evaluated in rats administered the bacterial strain alone, the prebiotic alone, or the synbiotic combination. Strain-specific quantitative real-time PCR showed that the addition of GOS increased B. adolescentis IVS-1 abundance in the distal intestine by nearly 2 logs compared to rats receiving only the probiotic. Illumina 16S rRNA sequencing not only confirmed the increased establishment of IVS-1 in the intestine but also revealed that the strain was able to outcompete the resident Bifidobacterium population when provided with GOS. In conclusion, this study demonstrated that IVS can be used to successfully formulate a synergistic synbiotic that can substantially enhance the establishment and competitiveness of a putative probiotic strain in the gastrointestinal tract.T he mechanistic role of the gastrointestinal (GI) microbiota and its metabolites in maintaining human health has been well demonstrated (1-3). Gut microbes provide several important benefits for their host, including provision of nutrients, development and maturation of the immune system, and protection against pathogens via colonization resistance (4). However, the gut microbiota may also contribute to obesity, inflammatory and autoimmune diseases, and other chronic disease states (5-7). Such diseases are often associated with compositional alterations in the fecal microbiota, a condition referred to as "dysbiosis" (8). Given that the presence of specific types of bacteria and their relative abundance within the gut are considered to affect host health, there is much interest in devising strategies that modulate gut microbiota composition and potentially redress disease-related dysbiotic patterns (9).Dietary approaches currently available to modulate the gut microbiota include prebiotics (10-12), fermentable fibers (13, 14), probiotics (or live biotherapeutics) (15), and synbiotics, which are a combination of a probiotic and a prebiotic (11, 16). According to Kolida and Gibson (16), synbiotics can be either complementary or synergistic. Complementary synbiotics consist of a probiotic and a prebiotic selected to independently confer benefits to the host. In contrast, sy...

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“…It has been discussed that some beneficial effects of probiotics like Bifidobacterium spp. result from the stabilization of the intestinal barrier and from changes in the composition of the intestinal microbiota . Results obtained in a mouse model showed that Bifidobacterium spp.…”

Section: Discussionmentioning

confidence: 99%

“…result from the stabilization of the intestinal barrier and from changes in the composition of the intestinal microbiota. 29 Results obtained in a mouse model showed that Bifidobacterium spp. lowered gut endotoxin concentration and enhanced mucosal immunity.…”

Section: Discussionmentioning

confidence: 99%

Effect of prebiotics ofAgave salmianafed to healthy Wistar rats

Jasso-Padilla

Juárez-Flores

Álvarez-Fuentes

et al. 2016

J. Sci. Food Agric.

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Bifidobacterium adolescentis protects from the development of nonalcoholic steatohepatitis in a mouse model

Cited by 66 publications

References 45 publications

Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time

Diets rich in fructose, fat or fructose and fat alter intestinal barrier function and lead to the development of nonalcoholic fatty liver disease over time

In Vivo Selection To Identify Bacterial Strains with Enhanced Ecological Performance in Synbiotic Applications

Effect of prebiotics ofAgave salmianafed to healthy Wistar rats

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