Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: a randomized, double-blind, placebo-controlled study

Hojsak, Iva; Pivac, Višnja Tokić; Pavić, Ana Močić; Pasini, Agneza Marija; Kolaček, Sanja

doi:10.3945/ajcn.114.102004

Cited by 40 publications

(41 citation statements)

References 16 publications

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“…The other study, performed at the same centre, used B. animalis subsp. lactis (BB‐12) at the same dose and was not able to prove positive effect . In conclusion, although there is evidence that some probiotic strains could have been effective in preventing RTIs, the evidence is insufficient to recommend their routine use.…”

Section: Methodsmentioning

confidence: 94%

Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups

et al. 2018

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AimThe use of probiotics has been covered by many guidelines, position papers and evidence‐based recommendations, but few have referred to specific patient groups or clinical indications. This review summarises recommendations and scientifically credited guidelines on the use of probiotics for children with selected clinical conditions and provides practice points.MethodsAn expert panel was convened by the European Paediatric Association in June 2017 to define the relevant clinical questions for using probiotics in paediatric health care and review and summarise the guidelines, recommendations, position papers and high‐quality evidence.ResultsThe panel found that specific probiotic strains were effective in preventing antibiotic‐associated and nosocomial diarrhoea, treating acute gastroenteritis and treating infantile colic in breastfed infants. However, special caution is indicated for premature infants, immunocompromised and critically ill patients and those with central venous catheters, cardiac valvular disease and short‐gut syndrome. This review discusses the safety of using probiotics in selected groups of paediatric patients and the quality of the available products providing practice points based on proved findings.ConclusionEfficacy of probiotics is strain specific. Their benefits are currently scientifically proven for their use in selected clinical conditions in children and not recommended for certain patient groups.

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Section: Methodsmentioning

confidence: 94%

Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups

et al. 2018

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“…lactis BB-12 was not effective in preventing nosocomial infections (gastrointestinal and respiratory infections) occurring >48 h after admission in hospitalised children older than 1 year. 30 Taken together, these findings document that not all probiotics are equally effective for preventing nosocomial diarrhoea.…”

Section: Strengths and Limitationsmentioning

confidence: 92%

Systematic review with meta‐analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children

Urbańska

Gieruszczak‐Białek

Szajewska

2016

Aliment Pharmacol Ther

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“…The incidence of nosocomial infections in children in developed countries is still high, ranging from 8% to 30%, and standard preventive measures, such as increased hygiene, are not sufficiently efficacious. 17 They organized a randomized, doubleblind, placebo-controlled trial in 727 hospitalized children. The children were randomly assigned to receive placebo therapy (n = 365) or Bifidobacteriumanimalis subsp.…”

Section: Discussionmentioning

confidence: 99%

Study of role of oral probiotics in patients on ventilator in paediatric Intensive Care Unit at tertiary care center

Chawan¹,

Aswathy²

2020

Int J Contemp Pediatr

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Background: The normal intestinal microbiota of critically ill patients is altered and replaced by pathogens. Any significant insult to the gut or alteration to its microbiota plays a role in promoting systemic inflammation and infection in the critically ill population. Probiotics may affect other body sites in addition to the GI tract , and they can have applications in a variety of populations, including healthy individuals, children, elderly, immunocompromised and genetically predisposed individuals. These studies the effect of probiotics in pediatric population on mechanical ventilation in a tertiary care hospital.Methods: Present study was conducted in a PICU of a tertiary care teaching hospital in children aged 12 years or less admitted to PICU and who were likely to need mechanical ventilation for more than 48 h were recruited.Results: In present study 25 patients were recruited in each group i.e. case (probiotics) group and control group. Most common age group among case group was 6-8 years (44 %), while 9-12 years (36 %) was most common age group in control group. Mean age was comparable in both groups (7.6±3.5 years in case group and 7.9±4.1 years in control group). In both groups septic shock and pneumonia were most common diagnosis followed by admission due to miscellaneous cause. In both groups mechanical ventilation was used due to respiratory failure and shock. Outcome was compared in both groups. Authors noted a statistically significant difference in duration of ICU stay, duration of hospital stay and duration of mechanical ventilation, between case 7 control group (p<0.05). In terms of overall mortality, authors did not noted any significant difference among groups.Conclusions: Authors noted a statistically significant difference in duration of ICU stay, duration of hospital stay and duration of mechanical ventilation, between case and control group (p<0.05).

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Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: a randomized, double-blind, placebo-controlled study

Cited by 40 publications

References 16 publications

Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups

Guidance on the use of probiotics in clinical practice in children with selected clinical conditions and in specific vulnerable groups

Systematic review with meta‐analysis: Lactobacillus reuteri DSM 17938 for diarrhoeal diseases in children

Study of role of oral probiotics in patients on ventilator in paediatric Intensive Care Unit at tertiary care center

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