Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells

Shirasawa, Yukio; Shibahara-Sone, Harue; Iino, Tetsuo; Ishikawa, Fumihiko

doi:10.3168/jds.2010-3274

Cited by 34 publications

(29 citation statements)

References 32 publications

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“…ifidobacteria are intensively exploited by the food industry due to the presumed health beneficial effects they exert on the human host (1)(2)(3)(4)(5). However, the molecular mechanisms underlying these proclaimed health-promoting activities are still largely unknown.…”

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confidence: 99%

Comparative Genomics of Bifidobacterium animalis subsp. lactis Reveals a Strict Monophyletic Bifidobacterial Taxon

Milani

Duranti²,

Lugli³

et al. 2013

Appl Environ Microbiol

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Strains of Bifidobacterium animalis subsp. lactis are extensively exploited by the food industry as health-promoting bacteria, although the genetic variability of members belonging to this taxon has so far not received much scientific attention. In this article, we describe the complete genetic makeup of the B. animalis subsp. lactis Bl12 genome and discuss the genetic relatedness of this strain with other sequenced strains belonging to this taxon. Moreover, a detailed comparative genomic analysis of B. animalis subsp. lactis genomes was performed, which revealed a closely related and isogenic nature of all currently available B. animalis subsp. lactis strains, thus strongly suggesting a closed pan-genome structure of this bacterial group.

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confidence: 99%

Comparative Genomics of Bifidobacterium animalis subsp. lactis Reveals a Strict Monophyletic Bifidobacterial Taxon

Milani

Duranti²,

Lugli³

et al. 2013

Appl Environ Microbiol

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“…In these environments, bifidobacteria reach a particularly high relative abundance as part of the infant gut microbiota (3)(4)(5), and this early life prevalence supports their purported role as modulators of various metabolic and immune activities of their immature host (1). Various members of the genus Bifidobacterium have attracted substantial scientific and commercial interest due to various professed beneficial health effects that they exert on their human host (6)(7)(8)(9)(10). Currently, the genus Bifidobacterium includes 47 taxa, involving 38 species and 9 subspecies (2,(11)(12)(13)(14).…”

mentioning

confidence: 99%

Genomic Encyclopedia of Type Strains of the Genus Bifidobacterium

Milani

Lugli

Duranti

et al. 2014

Appl Environ Microbiol

219

225

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e Bifidobacteria represent one of the dominant microbial groups that are present in the gut of various animals, being particularly prevalent during the suckling stage of life of humans and other mammals. However, the overall genome structure of this group of microorganisms remains largely unexplored. Here, we sequenced the genomes of 42 representative (sub)species across the Bifidobacterium genus and used this information to explore the overall genetic picture of this bacterial group. Furthermore, the genomic data described here were used to reconstruct the evolutionary development of the Bifidobacterium genus. This reconstruction suggests that its evolution was substantially influenced by genetic adaptations to obtain access to glycans, thereby representing a common and potent evolutionary force in shaping bifidobacterial genomes.

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“…2a, b). In previous reports, some probiotic strains such as lactobacilli, lactococci, and bifidobacteria were reported to prevent IL-8 production from gastric epithelial cells inoculated with H. pylori [2,17,29,30]. Kim et al reported that Lactococcus lactis strain SL3 reduced IL-8 levels in MKN45 and AGS cells cultured with H. pylori [30].…”

Section: Discussionmentioning

confidence: 96%

Lactobacillus paracasei strain 06TCa19 suppresses inflammatory chemokine induced by Helicobacter pylori in human gastric epithelial cells

et al. 2017

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Helicobacter (H.) pylori infection is an important risk factor for gastric cancer that causes gastric inflammation. Inflammatory chemokines such as interleukin (IL)-8 and regulated on activation normal T cell expressed and secreted (RANTES) are elevated in the gastric mucosa by H. pylori. This study aimed to investigate the effects of Lactobacillus paracasei strain 06TCa19, a probiotic strain, on IL-8 and RANTES expression and production induced by H. pylori using human gastric epithelial cell lines. Strain 06TCa19 was shown to suppress H. pylori-mediated elevation of gene expression related to these chemokines in MKN45 cells. The strain also suppressed the increase in IL-8 and RANTES products induced by H. pylori in AGS cells as well as in MKN45 cells. In MKN45 cells inoculated with H. pylori, strain 06TCa19 was shown to downregulate the activation of NF-κB and p38 MAPK signaling pathways. Additionally, the level of the CagA virulence protein of H. pylori in the MKN45 cells and the number of viable H. pylori adhering to MKN45 cells decreased with the addition of strain 06TCa19. Moreover, the strain 06TCa19 notably increased lactic acid in the supernatant of MKN45 cells. Thus, lactic acid released from strain 06TCa19 might have inhibited the adhesion of H. pylori to MKN45 cells and prevented the insertion of H. pylori CagA into the cells, and elevation of IL-8 and RANTES genes and proteins might be suppressed by downregulating the NF-κB and p38 MAPK pathways. Therefore, use of strain 06TCa19 may prevent H. pylori-associated gastric inflammation.

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Bifidobacterium bifidum BF-1 suppresses Helicobacter pylori-induced genes in human epithelial cells

Cited by 34 publications

References 32 publications

Comparative Genomics of Bifidobacterium animalis subsp. lactis Reveals a Strict Monophyletic Bifidobacterial Taxon

Comparative Genomics of Bifidobacterium animalis subsp. lactis Reveals a Strict Monophyletic Bifidobacterial Taxon

Genomic Encyclopedia of Type Strains of the Genus Bifidobacterium

Lactobacillus paracasei strain 06TCa19 suppresses inflammatory chemokine induced by Helicobacter pylori in human gastric epithelial cells

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