Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study

Tanaka, Keiko; Tsukahara, Takamitsu; Yanagi, Takahide; Nakahara, Sayuri; Furukawa, Ouki; Tsutsui, Hidemi; Koshida, Shigeki

doi:10.3390/nu9030195

Cited by 22 publications

(24 citation statements)

References 33 publications

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“…The correlation analysis showed that the relative abundances of Lachnospiraceae_XPB1014_group, Rikenellaceae_RC9_gut_group, Ruminococcaceae_UCG-002 and Prevotella_2 were negatively correlated with serum IgG content; the lower abundances of these genera triggered by CPB addition indicated that CPB was able to increase host immunity, corresponding with the high serum IgG concentration caused by CPB administration. The previous report showed that probiotics could increase host serum IgG levels [30,31], in agreement with this study. This study demonstrated that oral administration of CPB enhanced host intestinal homeostasis by modulating the composition of gut microbiota for improving piglet production performance.…”

Section: Discussionsupporting

confidence: 93%

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

Yang

Chang

et al. 2020

Animals

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Simple Summary: In order to find antibiotic substitutes for weaned piglet health and growth, compound probiotics and berberine (CPB) were selected in this study. The results indicated that CPB could replace antibiotics to improve piglet health and decrease mortality, diarrhea and rejection rates. CPB was also able to regulate fecal microbiota as well as improve protein digestibility and serum biochemical parameters. Therefore, CPB might be a good antibiotic alternative in piglet production performance.Abstract: This study was conducted to investigate the effects of dietary supplementation with compound probiotics and berberine (CPB) on growth performance, nutrient digestibility and fecal microflora in weaned piglets. A total of 200 piglets 35 days old were randomly allocated to 5 groups, 4 replications in each group, and 10 piglets in each replication. Group A was the basal diet; group B was supplemented with antibiotics and zinc oxide; groups C, D and E were supplemented with 0.06%, 0.12% and 0.18% CPB, respectively. The experimental period was 42 d. The results indicated that there were no significant differences in average daily feed intake (ADFI), average daily gain (ADG) and feed conversion rate (FCR) among five groups (p > 0.05). However, mortality, diarrhea and rejection rates in the control group were higher than that in other groups. CPB could increase protein digestibility and serum IgG content (p < 0.05), while it could decrease serum urea nitrogen content and alkaline phosphatase activity (p < 0.05). Analysis of fecal microbiota showed that the relative abundances of Bacteroides and Firmicutes were increased, while the relative abundances of opportunistic pathogens such as Spirochaetae and Protebactreria were dramatically decreased in piglets fed with CPB or antibiotics, compared with the control group. Furthermore, CPB intervention increased the relative abundances of Prevotella_9, Megasphaera and Prevotella_2, while decreased the relative abundance of Prevotellaceae_NK3B31_group. Correlation analysis revealed that there was good correlation between serum indexes and fecal microbiota. It was suggested that CPB might be a promising antibiotic alternative for improving piglet health and immunity, decreasing mortality by positively altering gut microbiota.

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Section: Discussionsupporting

confidence: 93%

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

Yang

Chang

et al. 2020

Animals

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“…These data revealed that oral administration of L. frumenti contributes to the intestinal mucosal immunity performed by sIgA and anti-infection immunity performed by IgG and antiviral immunity performed by IFN-γ. Recent evidences have demonstrated that some probiotics [including L. casei ( Ogawa et al, 2001 ; Galdeano and Perdigon, 2006 ), Bifidobacterium animalis ( Martins et al, 2009 ), Bifidobacterium bifidum , Bifidobacterium infantis ( Qiao et al, 2002 ), Bifidobacterium lactis ( Shu and Gill, 2001 ), L. helveticus ( Leblanc et al, 2004 ), Saccharomyces boulardii ( Rodrigues et al, 2000 ; Qamar et al, 2001 ), L. acidophilus , and Bifidobacterium bifidum ( Shandilya et al, 2016 )] facilitate increasing the host sIgA levels and some probiotics [including Bifidobacterium bifidum ( Tanaka et al, 2017 ) and Bacillus subtilis ( Guo et al, 2017 )] contribute to increase the host serum IgG levels. Thus, our findings facilitate our increasing understandings of the regulatory role of probiotics in host immune system.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus frumenti Facilitates Intestinal Epithelial Barrier Function Maintenance in Early-Weaned Piglets

Chen

Zheng

et al. 2018

Front. Microbiol.

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Increased intestinal epithelial barrier function damages caused by early weaning stress have adverse effects on swine health and feed utilization efficiency. Probiotics have emerged as the promising antibiotic alternatives used for intestinal barrier function damage prevention. Our previous data showed that Lactobacillus frumenti was identified as a predominant Lactobacillus in the intestinal microbiota of weaned piglets. However, whether the intestinal epithelial barrier function in piglets was regulated by L. frumenti is still unclear. Here, piglets received a PBS vehicle or PBS suspension (2 ml, 108 CFU/ml) containing the L. frumenti by oral gavage once a day during the period of 6–20 days of age prior to early weaning. Our data demonstrated that oral administration of L. frumenti significantly improved the intestinal mucosal integrity and decreased the serum endotoxin and D-lactic acid levels in early-weaned piglets (26 days of age). The intestinal tight junction proteins (including ZO-1, Occludin, and Claudin-1) were significantly up-regulated by L. frumenti administration. The serum immunoglobulin G (IgG) levels, intestinal secretory immunoglobulin A (sIgA) levels, and interferon-γ (IFN-γ) levels were significantly increased by L. frumenti administration. Furthermore, our data revealed that oral administration of L. frumenti significantly increased the relative abundances of health-promoting microbes (including L. frumenti, Lactobacillus gasseri LA39, Parabacteroides distasonis, and Kazachstania telluris) and decreased the relative abundances of opportunistic pathogens (including Desulfovibrio desulfuricans and Candida humilis). Functional alteration of the intestinal bacterial community by L. frumenti administration was characterized by the significantly increased fatty acids and protein metabolism and decreased diseases-associated metabolic pathways. These findings suggest that L. frumenti facilitates intestinal epithelial barrier function maintenance in early-weaned piglets and may be a promising antibiotic alternative used for intestinal epithelial barrier function damage prevention in mammals.

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“…This study was registered in the UMIN (University Hospital Medical Information Network in Japan) Clinical Trial Registry (UMIN000020520) and was conducted in accordance with the Declaration of Helsinki. We used fecal samples collected for our previously reported study [25] after obtaining written informed consent from the guardians of the infants according to the approval provided by the Institutional Review Board of Shiga University of Medical Science (approval number 24-151), Japan.…”

Section: Methodsmentioning

confidence: 99%

“…The subject and protocol have been described previously [25], and this study is a secondary analysis focusing on bifidobacterial colonization in LBW infants. The subjects of the study were selected from LBW infants (1500–2500 g) who were admitted in the neonatal intensive care unit (NICU) of Shiga University of Medical Science Hospital between March 2013 and May 2014, and whose legal guardians provided written informed consent for participation in the study within 48 h after birth.…”

Section: Methodsmentioning

confidence: 99%

Poor Bifidobacterial Colonization Is Associated with Late Provision of Colostrum and Improved with Probiotic Supplementation in Low Birth Weight Infants

Tanaka

Nakamura²,

Terahara³

et al. 2019

Nutrients

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This study aimed to evaluate the association between bifidobacterial colonization in low birth weight infants and perinatal factors, including the timing of initial colostrum and the effect of probiotics on this colonization. In this non-randomized controlled trial, we enrolled 98 low-birth-weight infants from a neonatal intensive care unit (NICU) in Japan. Infants were divided into three groups: group N (no intervention), group H (received non-live bifidobacteria), and group L (received live bifidobacteria). The number of bifidobacteria in the infants’ stools at 1 month of age was measured using real-time polymerase chain reaction (PCR). We divided infants into “rich bifidobacteria” (≥104.8 cells/g feces) and “poor bifidobacteria” (<104.8 cells/g feces) subgroups. The ratio of “rich bifidobacteria” infants was 20/31, 34/36, and 30/30 in groups N, H, and L, respectively. In group N, the “rich bifidobacteria” group received first colostrum significantly earlier than the “poor bifidobacteria” group (1 day vs. 4 days, P < 0.05). Compared with the N group, both groups H and L had a significantly high proportion of “rich bifidobacteria” infants (P < 0.05). Bifidobacterial colonization was poor in premature infants at 1 month compared with term infants, and the level of colonization was associated with the timing of initial provision of colostrum. Providing probiotics to premature infants can improve bifidobacterial colonization.

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Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study

Cited by 22 publications

References 33 publications

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

Dietary Supplementation with Compound Probiotics and Berberine Alters Piglet Production Performance and Fecal Microbiota

Lactobacillus frumenti Facilitates Intestinal Epithelial Barrier Function Maintenance in Early-Weaned Piglets

Poor Bifidobacterial Colonization Is Associated with Late Provision of Colostrum and Improved with Probiotic Supplementation in Low Birth Weight Infants

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