Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus

Lakshmanan, Arun Prasath; Shatat, Ibrahim F.; Zaidan, Sara Al; Jacob, Shana; Bangarusamy, Dhinoth Kumar; Alabduljabbar, Shaikha; Al‐Khalaf, Fawziya; Petroviski, Goran; Terranegra, Annalisa

doi:10.1016/j.biopha.2021.111736

Cited by 18 publications

(14 citation statements)

References 79 publications

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“…Also, a recent study suggested that gut-related metabolites are associated with autoimmunity and pathogenesis of latent autoimmune diabetes in adults, suggesting that the interaction between gut microbiota and diabetes could be mediated by certain metabolites ( 14 ). Furthermore, the gut microbiota and serum metabolites of T1D patients are also associated with the progression of microvascular ( 15 , 16 ) and macrovascular complications ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

et al. 2022

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BackgroundThe profile of gut microbiota, serum metabolites, and lipids of type 1 diabetes (T1D) patients with different human leukocyte antigen (HLA) genotypes remains unknown. We aimed to explore gut microbiota, serum metabolites, and lipids signatures in individuals with T1D typed by HLA genotypes.MethodsWe did a cross-sectional study that included 73 T1D adult patients. Patients were categorized into two groups according to the HLA haplotypes they carried: those with any two of three susceptibility haplotypes (DR3, DR4, DR9) and without any of the protective haplotypes (DR8, DR11, DR12, DR15, DR16) were defined as high-risk HLA genotypes group (HR, n=30); those with just one or without susceptibility haplotypes as the non-high-risk HLA genotypes group (NHR, n=43). We characterized the gut microbiome profile with 16S rRNA gene amplicon sequencing and analyzed serum metabolites with liquid chromatography-mass spectrometry.ResultsStudy individuals were 32.5 (8.18) years old, and 60.3% were female. Compared to NHR, the gut microbiota of HR patients were characterized by elevated abundances of Prevotella copri and lowered abundances of Parabacteroides distasonis. Differential serum metabolites (hypoxanthine, inosine, and guanine) which increased in HR were involved in purine metabolism. Different lipids, phosphatidylcholines and phosphatidylethanolamines, decreased in HR group. Notably, Parabacteroides distasonis was negatively associated (p ≤ 0.01) with hypoxanthine involved in purine metabolic pathways.ConclusionsThe present findings enabled a better understanding of the changes in gut microbiome and serum metabolome in T1D patients with HLA risk genotypes. Alterations of the gut microbiota and serum metabolites may provide some information for distinguishing T1D patients with different HLA risk genotypes.

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Section: Introductionmentioning

confidence: 99%

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

et al. 2022

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“…LPS, a bacterial cell wall component, may be a factor influencing hypertension by gut microbiota. Upregulation of LPS biosynthesis was observed in hypertension group 6,48,77,112,113 . LPS can increase gut and neuroinflammation response in hypertension, 114 which may be a mechanism connecting gut microbiota with hypertension 115 .…”

Section: The Potential Mechanisms Involved In the Regulation Between ...mentioning

confidence: 86%

Regulatory effect of gut microbes on blood pressure

Yan

Sun

Zhou

et al. 2022

Anim Models and Exp Med

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Hypertension is an important global public health issue because of its high morbidity as well as the increased risk of other diseases. Recent studies have indicated that the development of hypertension is related to the dysbiosis of the gut microbiota in both animals and humans. In this review, we outline the interaction between gut microbiota and hypertension, including gut microbial changes in hypertension, the effect of microbial dysbiosis on blood pressure (BP), indicators of gut microbial dysbiosis in hypertension, and the microbial genera that affect BP at the taxonomic level. For example, increases in Lactobacillus, Roseburia, Coprococcus, Akkermansia, and Bifidobacterium are associated with reduced BP, while increases in Streptococcus, Blautia, and Prevotella are associated with elevated BP. Furthermore, we describe the potential mechanisms involved in the regulation between gut microbiota and hypertension. Finally, we summarize the commonly used treatments of hypertension that are based on gut microbes, including fecal microbiota transfer, probiotics and prebiotics, antibiotics, and dietary supplements. This review aims to find novel potential genera for improving hypertension and give a direction for future studies on gut microbiota in hypertension.

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“…These mechanisms could lead to pathological changes such as white matter lesions, blood brain barrier damage and neurovascular unit damage [136]. In addition, another study found that the reduction of intestinal flora, such as bifidobacteria, could lead to hypertension in children with T1DM [137]. Controlling blood pressure was helpful for reducing the incidence of CI in T1DM patients.…”

Section: Discussionmentioning

confidence: 99%

Corresponding risk factors between cognitive impairment and type 1 diabetes mellitus: A narrative review

Jin

Shibata

Yin

et al. 2022

Heliyon

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Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus

Cited by 18 publications

References 79 publications

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

High-risk genotypes for type 1 diabetes are associated with the imbalance of gut microbiome and serum metabolites

Regulatory effect of gut microbes on blood pressure

Corresponding risk factors between cognitive impairment and type 1 diabetes mellitus: A narrative review

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