Bifidogenic effect of whole-grain wheat during a 12-week energy-restricted dietary intervention in postmenopausal women

Christensen, Ellen Gerd; Licht, Tine Rask; Kristensen, Mette; Bahl, Martin Iain

doi:10.1038/ejcn.2013.207

Cited by 41 publications

(27 citation statements)

References 42 publications

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“…Nevertheless, TER was observed to be consistently higher in the CON than both the XOS and BIF groups from around 12 hours until termination at 24 hours, indicating an increase in permeability in the Caco-2 monolayer during exposure to caecal water from XOS and BIF (Figure 5B). This is consistent with a previously observed trend for a negative correlation between TER and relative abundance of bifidobacteria [11]. Caecal-water collected from CON, XOS of BIF animals increased TER during 24-hours significantly more than water, which was used as control.…”

Section: Discussionsupporting

confidence: 92%

“…Caecal-water collected from CON, XOS of BIF animals increased TER during 24-hours significantly more than water, which was used as control. This suggests that caecal water positively affects tight-junction interaction, which is consistent with similar observations on faecal-water [11]. Expression levels of occludin genes in colonic tissue were significantly higher in the XOS group than in the CON group.…”

Section: Discussionsupporting

confidence: 88%

“…Effects of gut content on intestinal integrity may also be assessed in vitro by examining the effect of metabolites from the community found in e.g. faecal water on trans-epithelial resistance (TER) in epithelial cell monolayers [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

“…Also, we have recently shown a trend for an inverse association between the relative abundance of Bifidobacterium spp. in human faeces and the effect of faecal water on trans-epithelial resistance (TER) [11]. This however does not necessarily implicate that bifidobacteria or lactobacilli are involved in the observed adverse effects, but the effects could be attributed to other factors, such as changes in non-investigated bacterial groups.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats

et al. 2014

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BackgroundConsumption of prebiotics may modulate gut microbiota, subsequently affecting the bacterial composition, metabolite profile, and human health. Previous studies indicate that also changes in intestinal integrity may occur. In order to explore this further we have investigated the effect of the putative prebiotic xylo-oligosaccharides (XOS) on the gut microbiota and intestinal integrity in male Wistar rats. As changes in intestinal integrity may be related to the expected bifidogenic effect of XOS, we additionally addressed effects of supplementation with a commensal Bifidobacterium pseudolongum (BIF) isolated from the same breed of laboratory rats.ResultsChanges in faecal and caecal bacterial composition determined by 16S rRNA gene sequencing and quantitative PCR for selected bacterial groups revealed that the overall bacterial composition did not differ markedly between the control (CON), XOS, and BIF groups, when correcting for multiple comparisons. However as hypothesised, the relative abundance of Bifidobacterium spp. was increased in XOS-fed rats as compared to CON in faecal samples after the intervention. Also Lactobacillus spp. was increased in both the XOS and BIF groups in caecum content compared to CON. Intestinal permeability determined in vivo by FITC-dextran permeability and in vitro using extracted caecum water in trans-epithelial resistance (TER) assay showed no effect on intestinal integrity in either the XOS or the BIF groups. However, the expression of occludin, which is part of the tight junction complex, was increased in the XOS group compared to the CON group.ConclusionsSupplementation with XOS or a commensal Bifidobacterium pseudolongum had very limited effects on intestinal integrity in rats as only significant change in expression of a single tight junction protein gene was found for the XOS group.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats

et al. 2014

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“…Another intervention study with whole grain vs. refined wheat documented significantly higher (P 5 0.04) numbers of Bifidobacterium spp. (43). Thus, whole grains have a potential to influence microbial composition, although the effect is less pronounced than when using prebiotics with a dominating polysaccharide (RS, inulin) or oligosaccharide (41,44).…”

Section: Impact Of Carbohydrates On Microbial Composition In the Largmentioning

confidence: 97%

Microbial Degradation of Whole-Grain Complex Carbohydrates and Impact on Short-Chain Fatty Acids and Health

Knudsen

2015

Advances in Nutrition

149

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Whole-grain cereals have a complex dietary fiber (DF) composition consisting of oligosaccharides (mostly fructans), resistant starch, and nonstarch polysaccharides (NSPs); the most important are arabinoxylans, mixed-linkage β(1,3; 1,4)-d-glucan (β-glucan), and cellulose and the noncarbohydrate polyphenolic ether lignin. The highest concentration of NSPs and lignin is found in the outer cell layers of the grain, and refined flour will consequently be depleted of a large proportion of insoluble DF components. The flow and composition of carbohydrates to the large intestine are directly related to the intake of DF. The type and composition of cereal DF can consequently be used to modulate the microbial composition and activity as well as the production and molar ratios of short-chain fatty acids (SCFAs). Arabinoxylans and β-glucan in whole-grain cereals and cereal ingredients have been shown to augment SCFA production, with the strongest relative effect on butyrate. When arabinoxylans were provided as a concentrate, the effect was only on total SCFA production. Increased SCFA production in the large intestine was shown by the concentration in the portal vein, whereas the impact on the concentration in peripheral blood was less because the majority of propionate and butyrate is cleared in the liver. Active microbial fermentation with increased SCFA production reduced the exposure of potentially toxic compounds to the epithelium, potentially stimulating anorectic hormones and acting as signaling molecules between the gut and the peripheral tissues. The latter can have implications for insulin sensitivity and glucose homeostasis.

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Dietary approaches to stop hypertension (DASH) diet improves hepatic fibrosis, steatosis and liver enzymes in patients with non-alcoholic fatty liver disease: a randomized controlled trial

Sangouni,

Nadjarzadeh,

Rohani

et al. 2023

Eur J Nutr

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Bifidogenic effect of whole-grain wheat during a 12-week energy-restricted dietary intervention in postmenopausal women

Abstract: The present study shows that whole-grain wheat consumption increases the abundance of bifidobacteria compared to baseline and may have indirect effects on the integrity of the intestinal wall.

Cited by 41 publications

References 42 publications

Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats

Dietary Xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats

Microbial Degradation of Whole-Grain Complex Carbohydrates and Impact on Short-Chain Fatty Acids and Health

Dietary approaches to stop hypertension (DASH) diet improves hepatic fibrosis, steatosis and liver enzymes in patients with non-alcoholic fatty liver disease: a randomized controlled trial

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