Biflavonoids and Oligomeric Flavonoids from Food

Yue, Tianli; Sheng, Qinglin; Luo, Yane; Xiao, Zhengcao; Wang, Yuan; Song, Wei; Yan, Min; Niu, Haili; Zhang, Ting; Li, Na

doi:10.1007/978-981-15-4148-3_7

Cited by 6 publications

(3 citation statements)

References 131 publications

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“…Oligomeric flavonoids or specifically biflavonoids have gained wide attention recently due to their health promotion effects and fascinating flavors with proanthocyanidin being the largest class of flavonoid polymer and found in various appealing-colored fruits and plants [ 237 ]. Three subgroups of proanthocyanidin (i.e., procyanidin, prodelphinidin, propelargonidin) differing in their monomers have been identified, yet their simultaneous inhibition against α-glucosidase and α-amylase received disproportionated concerns.…”

Section: Resultsmentioning

confidence: 99%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2024

Nat. Prod. Bioprospect.

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Diabetes mellitus remains a major global health issue, and great attention is directed at natural therapeutics. This systematic review aimed to assess the potential of flavonoids as antidiabetic agents by investigating their inhibitory effects on α-glucosidase and α-amylase, two key enzymes involved in starch digestion. Six scientific databases (PubMed, Virtual Health Library, EMBASE, SCOPUS, Web of Science, and WHO Global Index Medicus) were searched until August 21, 2022, for in vitro studies reporting IC50 values of purified flavonoids on α-amylase and α-glucosidase, along with corresponding data for acarbose as a positive control. A total of 339 eligible articles were analyzed, resulting in the retrieval of 1643 flavonoid structures. These structures were rigorously standardized and curated, yielding 974 unique compounds, among which 177 flavonoids exhibited inhibition of both α-glucosidase and α-amylase are presented. Quality assessment utilizing a modified CONSORT checklist and structure–activity relationship (SAR) analysis were performed, revealing crucial features for the simultaneous inhibition of flavonoids against both enzymes. Moreover, the review also addressed several limitations in the current research landscape and proposed potential solutions. The curated datasets are available online at https://github.com/MedChemUMP/FDIGA. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2024

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

show abstract

“…Oligomeric flavonoids or specifically biflavonoids have gained wide attention recently due to their health promotion effects and fascinating flavours with proanthocyanidin being the largest class of flavonoid polymer and found in various appealing-coloured fruits and plants. 268 Three subgroups of proanthocyanidin (i.e., procyanidin, prodelphinidin, propelargonidin) differing in their monomers have been identified, yet their simultaneous inhibition against α-glucosidase and α-amylase received disproportionated concerns. In the current review, a total of eleven articles and eight oligomeric flavonoids are included (Figure 11), with the most well-studied biflavonoid being amentoflavone (171).…”

Section: Oligomeric Flavonoidsmentioning

confidence: 99%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2023

Preprint

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Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α-glucosidase, two key starch digestive enzymes. Six scientific databases were queried up until August 21, 2022, for in vitro studies reporting the IC50 results of purified flavonoids on α-amylase or α-glucosidase, along with the respective data of acarbose control. A total of 339 articles were assessed as eligible and subjected to the data extraction process, resulting in 1643 retrieved flavonoid structures. Chemical structures were then rigorously standardized and curated to 974 unique compounds, in which 177 flavonoids showed both inhibitions against α-amylase and α-glucosidase. Quality assessment was conducted following a modified CONSORT checklist. The structure-activity relationships revealed that a double bond C2=C3 and a keto group C4=O is essential for simultaneous inhibition. The hydroxyl group at C3 is favourable for α-glucosidase inhibition but detrimental to the effect against α-amylase. Further notable features which affect α-glucosidase and α-amylase inhibition were also discussed. Several limitations were considered, including the inconsistency among included studies, language restriction, and the contemporaneity of the review. In conclusion, the systematic review has summarized some crucial findings in the investigation of flavonoids as dual-target inhibitors against α-glucosidase and α-amylase and proposed several orientations for future research.

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“…The inhibitory activity of puerarin towards α-glucosidase was found to be comparable to that of acarbose, with the IC50 values ranging from 75.60 to 524.08 µM 47,87,186,266,268 while its inhibitory activity against α-amylase was reported to be roughly 74 times lower than that of acarbose, reported in a study by Zhang et al Oligomeric flavonoids or specifically biflavonoids have gained wide attention recently due to their health promotion effects and fascinating flavours with proanthocyanidin being the largest class of flavonoid polymer and found in various appealing-coloured fruits and plants. 273 Three subgroups of proanthocyanidin (i.e., procyanidin, prodelphinidin, propelargonidin) differing in their monomers have been identified, yet their simultaneous inhibition against α-glucosidase and α-amylase received disproportionated concerns. In the current review, a total of 11 articles and 8 oligomeric flavonoids are included (Figure 17), with the most well-studied biflavonoid being amentoflavone (171).…”

Section: Isoflavonoidmentioning

confidence: 99%

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Lam,

Tran,

Pham

et al. 2023

Preprint

View full text Add to dashboard Cite

Diabetes mellitus remains a major global health burden and great attention is directed at natural therapeutics. This systematic review aimed to evaluate the potential of flavonoids as antidiabetic agents through their ability to inhibit α-amylase and α-glucosidase, two key starch digestive enzymes. Six scientific databases were queried up until August 21, 2022, for in vitro studies reporting the IC50 results of purified flavonoids on α-amylase or α-glucosidase, along with the respective data of acarbose control. A total of 339 articles were assessed as eligible and subjected to the data extraction process, resulting in 1643 retrieved structures, 177 compounds of which showed both inhibitions against α-amylase and α-glucosidase. Quality assessment was conducted following a modified CONSORT checklist. The structureactivity relationships revealed that a double bond C2=C3 and a keto group C4=O is essential for simultaneous inhibition. The hydroxyl group at C3 is favourable for α-glucosidase inhibition but detrimental to the effect against α-amylase. Further notable features which affect α-glucosidase and α-amylase inhibition were also discussed. Several limitations were considered, including the inconsistency among included studies, language restriction, and the contemporaneity of the review. In conclusion, the systematic review has summarized some crucial findings in the investigation of flavonoids as dual-target inhibitors against α-glucosidase and α-amylase and proposed several orientations for future research.

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Biflavonoids and Oligomeric Flavonoids from Food

Cited by 6 publications

References 131 publications

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

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