Biflorin inhibits the proliferation of gastric cancer cells by decreasing MYC expression

Barbosa-Jobim, Gleyce S.; Costa-Lira, Évelyn; Ralph, Ana Carolina Lima; Gregório, Luciana; Lemos, Telma L. G.; Burbano, Rommel Rodrı́guez; Calcagno, Danielle Queiroz; Smith, Marı́lia de Arruda Cardoso; Montenegro, Raquel Carvalho; Vasconcellos, Marne Carvalho de

doi:10.1016/j.tiv.2019.104735

Cited by 7 publications

(6 citation statements)

References 56 publications

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“…The results obtained by differential analysis and ROC evaluation of MYC which is the key genes in the core network were also clearly. We know that Myc can participate in the regulation of cell cycle, and its family of proteins includes c-Myc, n-Myc and l-Myc, among which c-Myc plays a role in cell proliferation, apoptosis [ 45 , 46 ], and presumably MYC is also a major target for therapy. It has been reported in the literature that TIMP1 is a biomarker for the diagnosis of GC and that TIMP1 can promote tumor invasion and metastasis, with higher levels associated with poorer prognosis [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

A study related to the treatment of gastric cancer with Xiang-Sha-Liu-Jun-Zi-Tang based on network analysis

Jiang,

Liu,

et al. 2023

Heliyon

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Section: Discussionmentioning

confidence: 99%

A study related to the treatment of gastric cancer with Xiang-Sha-Liu-Jun-Zi-Tang based on network analysis

Jiang,

Liu,

et al. 2023

Heliyon

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“…30,31,33 The ACP02 cancer cell line has been widely used as a model for the study of gastric cancer. [34][35][36] The cytotoxicity of the SM leaf extract was determined using the colorimetric MTT assay, which measures enzyme activity, predominantly succinate dehydrogenase. 37 The cytotoxicity was probably related to SM pro-oxidant effects in ACP02 cells since it increased intracellular ROS levels after 24 h of treatment at 200 μgÁml À1the same treatment length used in the MTT assay.…”

Section: Gene Expression Analysismentioning

confidence: 99%

Selective anticancer effects of Serjania marginata Casar. extract in gastric cells are mediated by antioxidant response

Serpeloni

Specian

Ribeiro

et al. 2021

Environmental Toxicology

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Gastric cancer is the fifth most common malignancy worldwide. Serjania marginata Casar. (SM) displays anti-inflammatory properties and has been used to treat gastrointestinal disorders. In the current study, we examined whether the hydroethanolic extract of SM leaves exerted cytotoxic, mutagenic, and protective effects in nontumor gastric epithelium cells (MNP01) and gastric adenocarcinoma cells (ACP02) in vitro and analyzed whether its action was selective. Initially, cell viability (MTT assay), cell cycle kinetics (flow cytometry), and cell proliferation (total protein content) were analyzed. In addition, genomic instability (cytokinesis-block micronucleus cytome assay), anti/pro-oxidant status (CM-H 2 DCFDA probe), and transcriptional expression (RT-qPCR) of genes related to cell cycle, cell death, and antioxidant defense were also evaluated. The SM extract was cytotoxic toward MNP01 and ACP02 cells at concentrations greater than 300 and 100 μgÁml À1 , respectively, and decreased protein content only toward ACP02 cells at 200 μg ml À1 . In ACP02 cells, the SM extract at 100 μgÁml À1 associated with doxorubicin (DXR; 0.2 μg ml À1 ) clearly promoted cell cycle arrest at the G2/M phase. The extract alone was not mutagenic to either cell type and reversed DXR-induced DNA damage and H 2 O 2 -induced oxidative stress in MNP01 cells. The gene expression experiments showed that SM hydroethanolic extract exerts an antioxidant response via NFE2L2 activation in nontumor gastric cells, and cell cycle arrest (G2/M) in ACP02 gastric cancer cells via the TP53 pathway. The selective action of SM indicates that it is a promising therapeutic agent to treat gastric diseases and merits further studies.

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“…24−27 Several recent studies have shown how unique and rare natural products from this plant genus can be used as scaffolds for semisynthetic studies, which result in the generation of novel screening libraries that have applications to not only drug discovery but also chemical biology. 7,9,28−30 For example, the serrulatane skeleton has been reported to exhibit various biological activities such as antibacterial, 20 anticancer, 27,31 and antihyperglycemic. 32 3,7,8-Trihydroxyserrulat-14-ene-19-oic acid (1), previously isolated from Eremophila microtheca aerial parts, has been identified as an attractive scaffold for structural modification due to its natural abundance and array of functional groups that could potentially serve as chemical handles for medicinal chemistry efforts.…”

mentioning

confidence: 99%

“…The endemic Australian plant genus Eremophila has been a rich source of new chemistry over the past four decades. − Numerous secondary metabolites reported from this source have been shown to exhibit novel and significant bioactivity. − Several recent studies have shown how unique and rare natural products from this plant genus can be used as scaffolds for semisynthetic studies, which result in the generation of novel screening libraries that have applications to not only drug discovery but also chemical biology. ,,− For example, the serrulatane skeleton has been reported to exhibit various biological activities such as antibacterial, anticancer, , and antihyperglycemic …”

mentioning

confidence: 99%

Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations

et al. 2023

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The known Eremophila microtheca-derived diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid (1) was targeted for large-scale purification, as this bioactive plant compound has proven to be an attractive scaffold for semisynthetic studies and subsequent library generation. Compound 1 was converted to a selectively protected trimethyl derivative, 3-hydroxy-7,8-dimethoxyserrulat-14-en-19-oic acid methyl ester (2), using simple and rapid methylation conditions. The resulting scaffold 2 was reacted with a diverse series of commercially available isocyanates to generate an 11-membered carbamate-based library. The chemical structures of the 11 new semisynthetic analogues were fully characterized by spectroscopic and spectrometric analysis. All natural products and semisynthetic compounds were evaluated for their anthelmintic, antimalarial, and anti-HIV activities. Compound 3 was shown to elicit the greatest antiplasmodial activity of all compounds tested, with IC50 values of 4.6 and 11.6 μM against Plasmodium falciparum 3D7 and Dd2, respectively. Compound 11 showed the greatest inhibition of development to fourth-stage Haemonchus contortus larvae (L4) and induction of a skinny (Ski) phenotype (67.5% of nematodes) at 50 μM. Compound 7, which inhibited 59.0% of HIV production at 100 μg/mL, was the carbamate analogue that displayed the best antiviral activity.

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Biflorin inhibits the proliferation of gastric cancer cells by decreasing MYC expression

Cited by 7 publications

References 56 publications

A study related to the treatment of gastric cancer with Xiang-Sha-Liu-Jun-Zi-Tang based on network analysis

A study related to the treatment of gastric cancer with Xiang-Sha-Liu-Jun-Zi-Tang based on network analysis

Selective anticancer effects of Serjania marginata Casar. extract in gastric cells are mediated by antioxidant response

Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations

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