Bifunctional probes reveal the rules of intracellular ether lipid transport
Kristin Böhlig,
Juan M. Iglesias-Artola,
H. Mathilda Lennartz
et al.
Abstract:Ether glycerophospholipids bear a long chain alcohol attached via an alkyl or vinyl ether bond at the sn1 position of the glycerol backbone. Emerging evidence suggests that ether lipids play a significant role in physiology and human health. However, their cellular functions remain largely unknown due to a lack of tools for identifying their subcellular localization and interacting proteins. Here, we address this methodological gap by synthesizing minimally modified bifunctional ether lipid probes by introduci… Show more
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