Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials

Yuan, Jiongpeng; Ye, Zhaoyi; Zeng, Yaoxun; Pan, Zhenxing; Feng, Zhonglin; Bao, Ying; Li, Yushan; Liu, Xujie; He, Yan; Feng, Qingling

doi:10.1016/j.mtbio.2022.100318

Cited by 19 publications

(11 citation statements)

References 132 publications

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“…Similarly, for OS treatment, Cosmegen (Dactinomycin), Denosumab, Doxorubicin Hydrochloride, Methotrexate Sodium, Trexall (Methotrexate Sodium), Xgeva (Denosumab), Zoledronic Acid, and Zometa are most used FDAapproved drugs. Typically, after surgical resection of OS, a critical bone defect is left behind [14,15]. Therefore, researchers focus on therapies synergistically promoting bone regeneration and killing residual tumor cells without systemic toxicity.…”

Section: Preclinical Studiesmentioning

confidence: 99%

“…After the surgical resection of OS, a critical-sized bone defect is created, which could need medical intervention using grafts or synthetic scaffolds to fill the bone defect. Several studies have focused on treatment strategies where bone tissue engineered scaffolds synergistically promote bone regeneration and kill residual tumor cells without causing systemic toxicity [14,15]. BTE enforces the participation of cells, biomaterials, and biomolecules, individually or in combination, to repair and regenerate the damaged or diseased bone [16].…”

Section: Introductionmentioning

confidence: 99%

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Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Shanmugavadivu,

Lekhavadhani,

Miranda

et al. 2024

Biomed. Mater.

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Osteosarcoma (OS) is a malignant bone neoplasm plagued by poor prognosis. Major treatment strategies include chemotherapy, radiotherapy, and surgery. Chemotherapy to treat OS has severe adverse effects due to systemic toxicity to healthy cells. A possible way to overcome the limitation is to utilize nanotechnology. Nanotherapeutics is an emerging approach in treating OS using nanoparticulate drug delivery systems. Surgical resection of OS leaves a critical bone defect requiring medical intervention. Recently, tissue engineered scaffolds have been reported to provide physical support to bone defects and aid multimodal treatment of OS. These scaffolds loaded with nanoparticulate delivery systems could also actively repress tumor growth and aid new bone formation. The rapid developments in nanotherapeutics and bone tissue engineering have paved the way for improved treatment efficacy for OS-related bone defects. This review focuses on current bifunctional nanomaterials-based tissue engineered scaffolds that use novel approaches such as magnetic hyperthermia, photodynamic therapy, photothermal therapy, bioceramic and polymeric nanotherapeutics against OS. With further optimization and screening, nanomaterials-based tissue engineered scaffolds could meet clinical applications for treating OS patients.

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Section: Preclinical Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Shanmugavadivu,

Lekhavadhani,

Miranda

et al. 2024

Biomed. Mater.

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“…These agents can be released over time, providing a sustained dose that targets the tumor cells. 11 In addition to drug delivery, the scaffold material itself can be designed to promote bone tissue regeneration. For example, the scaffold can be engineered to mimic the natural structure of bone tissue, providing a conducive environment for bone cells to grow and regenerate.…”

Section: Introductionmentioning

confidence: 99%

“…For example, the scaffold can be engineered to mimic the natural structure of bone tissue, providing a conducive environment for bone cells to grow and regenerate. 11 Reducing the fiber diameter to the nanometer scale confers several advantageous properties to the electrospun-nanofiber. These include a high surface area to volume ratio, abundant nanosized pores, and remarkable size uniformity, which closely resemble the structure of extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Strategically Designed Bifunctional Polydopamine Enwrapping Polycaprolactone-Hydroxyapatite-Doxorubicin Composite Nanofibers for Osteosarcoma Treatment and Bone Regeneration

Rezk,

Lee,

Kim

et al. 2024

ACS Appl. Mater. Interfaces

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This study presents a new multifunctional nanofibrous drug delivery system to provide effective combination therapy with enormous potential for the treatment of osteosarcoma. We developed a composite nanofiber scaffold comprising poly(ε-caprolactone) (PCL) and hydroxyapatite (HAp)-loaded doxorubicin (DOX) coated with polydopamine (PDA) to combine cancer cell inhibition with bone tissue regeneration. DOX was conjugated with HAp and then mixed with a PCL solution to prepare a PCL/ HAp−DOX (labeled PCLDH) nanofiber. Then, in situ polymerization of PDA on the PCLDH occurred to produce the PCLDH@PDA composite nanofiber. The morphology, XRD, FT-IR, wettability, photothermal characteristics, cumulative drug release, and in vitro bioactivities were evaluated. We found that the PDA coating not only enhanced the hydrophilic properties but also controlled drug release. The PCLDH@PDA composite scaffold significantly suppressed the proliferation of bone cancer cells initially and, consequently, improved the adhesion and proliferation of human mesenchymal stem cells (hMSCs). The PDA coating boosted the composite scaffold's bioactivity, as demonstrated through ALP activity, ARS assay, and biomineralization results. This strategy offers a promising dual-function scaffold to treat residual cancer and reconstruct defects after osteosarcoma surgery.

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“… 6–8 Nevertheless, tumor cells will persist in the bone tissue after surgery. 9 , 10 Therefore, we require a substance that is not only capable of promoting bone tissue regeneration and repairing bone defect, but also of destructing residual bone tumor cells. In bone tissue engineering, scaffolds serve a critical role by creating a three-dimensional (3D) environment for cell adhesion and proliferation.…”

Section: Introductionmentioning

confidence: 99%

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

Ma¹,

Zhang²,

Sun³

et al. 2023

IJN

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Bone tumors, including primary bone tumors, invasive bone tumors, metastatic bone tumors, and others, are one of the most clinical difficulties in orthopedics. Once these tumors have grown and developed in the bone system, they will interact with osteocytes and other environmental cells in the bone system’s microenvironment, leading to the eventual damage of the bone’s physical structure. Surgical procedures for bone tumors may result in permanent defects. The dual-efficacy of tissue regeneration and tumor treatment has made biomaterial scaffolds frequently used in treating bone tumors. 3D printing technology, also known as additive manufacturing or rapid printing prototype, is the transformation of 3D computer models into physical models through deposition, curing, and material fusion of successive layers. Adjustable shape, porosity/pore size, and other mechanical properties are an advantage of 3D-printed objects, unlike natural and synthetic material with fixed qualities. Researchers have demonstrated the significant role of diverse 3D-printed biological scaffolds in the treatment for bone tumors and the regeneration of bone tissue, and that they enhanced various performance of the products. Based on the characteristics of bone tumors, this review synthesized the findings of current researchers on the application of various 3D-printed biological scaffolds including bioceramic scaffold, metal alloy scaffold and nano-scaffold, in bone tumors and discussed the advantages, disadvantages, and future application prospects of various types of 3D-printed biological scaffolds. Finally, the future development trend of 3D-printed biological scaffolds in bone tumor is summarized, providing a theoretical foundation and a larger outlook for the use of biological scaffolds in the treatment of patients with bone tumors.

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Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials

Cited by 19 publications

References 132 publications

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Strategically Designed Bifunctional Polydopamine Enwrapping Polycaprolactone-Hydroxyapatite-Doxorubicin Composite Nanofibers for Osteosarcoma Treatment and Bone Regeneration

The Dual Effect of 3D-Printed Biological Scaffolds Composed of Diverse Biomaterials in the Treatment of Bone Tumors

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