Big Data and Machine Learning: What Is It and Can We Use It for 4R Nutrient Management?

Nigon, Leanna Leverich

doi:10.1002/crso.20296

Cited by 1 publication

(1 citation statement)

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“…Consequently, they can act as herbicides, fungicides, insecticides, nematicides, and acaricides 5 . Fertilizers are defined as substances containing nutrients that can be absorbed by plants, promoting their growth and enhancing productivity 6,7 …”

Section: Introductionmentioning

confidence: 99%

N‐Phenylnorbornenesuccinimide derivatives, agricultural defensive, and enzymatic target selection

Gomes,

Alvarenga,

Baia

et al. 2024

Pest Management Science

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BACKGROUNDFaced with the need to develop new herbicides with modes of action different of those observed for existing agrochemicals, one of the most promising strategies employed by synthetic chemists involves the structural modification of molecules found in natural products. Molecules containing amides, imides, and epoxides as functional groups are prevalent in nature and find extensive application in synthesizing more intricate compounds due to their biological properties. In this context, this paper delineates the synthesis of N‐phenylnorbornenesuccinimide derivatives, conducts biological assays, and carries out in silico investigation of the protein target associated with the most potent compound in plant organisms. The phytotoxic effects of the synthesized compounds (2–29) were evaluated on Allium cepa, Bidens pilosa, Cucumis sativus, Sorghum bicolor and Solanum lycopersicum.RESULTSReaction of endo‐bicyclo[2.2.1]hept‐5‐ene‐3a,7a‐dicarboxylic anhydride (1) with aromatic amines lead to the N‐phenylnorbornenesuccinic acids (2–11) with yields ranging from 75 to 90%. Cyclization of compounds (2–11) in the presence of acetic anhydride and sodium acetate afforded N‐phenylnorbornenesuccinimides (12–20) with yields varying from 65 to 89%. Those imides were then, subjected to epoxidation reaction to afford N‐phenylepoxynorbornanesuccimides (21–29) with yields from 60 to 90%. All compounds inhibited the growth of seedlings of the plants evaluated. Substance (23) was the most active against the plants tested, inhibiting in 100% the growth of all species in all concentrations. Cyclophilin was found as the enzymatic target of compound (23).CONCLUSIONThese findings suggest that derivatives of N‐phenylnorbornenesuccinimide are promising compounds in the quest for more selective and stable agrochemicals. This perspective reinforces the significance of these derivatives as potential innovative herbicides and emphasizes the importance of further exploring their biological activity on weeds.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%