IntroductionBig data analytics (BDA) is a course of action to examine large and complex data sets (i.e., big data) and select veiled information that can help organizations with efficient decision making [1]. The volume of data related to healthcare organizations has grown dramatically in past years and is expected to increase in coming years due to the use of innovative technologies [2]. Meanwhile, healthcare reimbursement methods are changing, and pay for performance is an emerging factor in the current healthcare environment. Recently, healthcare organizations have only focused on profit and have neglected to acquire the essential tools, infrastructure, and technologies for effective control of big data to ensure citizens' health care [3,4]. Big data incorporates features such as variety, velocity, and veracity. BDA techniques can be applied to the massive amount of prevailing patient-related medical information to analyze outcomes for improvement of the healthcare sector [5,6]. Using BDA in the healthcare sector will help inform each physician of the medical histories of individuals and the population and enable appropriate Abstract Big data analytics is gaining substantial attention due to its innovative contribution to decision making and strategic development across the healthcare field. Therefore, this study explored the adoption mechanism of big data analytics in healthcare organizations to inspect elements correlated to behavioral intention using the technology acceptance model and task-technology fit paradigm. Using a survey questionnaire, we analyzed 224 valid responses in AMOS v21 to test the hypotheses. Our results posit that the credentials of the technology acceptance model together with task-technology fit contribute substantially to the enhancement of behavioral intentions to use the big data analytics system in healthcare, ultimately leading towards actual use. Meanwhile, trust in and security of the information system also positively influenced the behavioral intention for use. Employee resistance to change is a key factor underlying failure of the innovative system in organizations and has been proven in this study to negatively moderate the relationship between intention to use and actual use of big data analytics in healthcare. Our results can be implemented by healthcare organizations to develop an understanding of the implementation of big data analytics and to promote psychological empowerment of employees to accept this innovative system. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.