, SPPE began to publish a series of reviews, editorials, and commentaries with the goal of synthesising evidence and providing a platform for discussing and advancing the state of the art in social psychiatry and psychiatric epidemiology. More than 2 years into these series, it is useful to take stock, look back, and provide an overview of what comes next.The series set off to synthesise and discuss evidence on the biological and psychological mechanisms through which social contexts and experiences increase risk of adverse mental health outcomes [1,2], reflecting the recent shift in theoretical and measurement foundations towards integrated models of aetiology. This included reviews and commentaries on gene-environment interactions [3][4][5][6] and on epigenetic [7,8], inflammatory [9,10], cognitive, affective [11][12][13], and neurobiological mechanisms [14] through which stress, adversity, and other key socio-environmental exposures may affect mental health. These reviews and commentaries highlight the rapid technological and subsequent scientific advances in psychiatry in uncovering mechanisms that underlie the epidemiological associations between adversity and illness that have been documented, since the advent of psychiatric epidemiology, yet also reveal a paradigm shift in its beginning stages of formation. In view of recent and impending revisions of the Diagnostic and Statistical Manual of Mental Disorders and International Classification of Diseases as well as movements towards non-binary classifications of psychiatric phenomena, the series then addressed current challenges in diagnostic classification in psychiatry [15][16][17][18][19], reviewing the enduring challenge of high comorbidity rates [19], methodological considerations in the use of latent variable models of psychopathology [16], and the evidence on transdiagnostic factors [17,18] that may underlie individual common mental disorders [17,18], personality disorders [18], and psychotic disorders [18,[20][21][22]. This was followed by reviews pulling together and discussing key findings from major epidemiological studies in the context of new challenges in the field and directions for future research [23][24][25][26][27][28][29][30]. It is abundantly clear, particularly from large-scale epidemiological studies, that the origins of most mental health problems trace back to childhood and adolescence [1] and the series continued with reviews and commentaries on youth mental health [31][32][33][34][35][36], including key findings from developmental epidemiology [32][33][34], protective and promotive factors [31], and the ongoing youth mental health reform in several countries [35,36]. These reviews and commentaries testify to the continued value and vigour of social epidemiological research in mental health. However, there are of course challenges that remain to be addressed. The rapid advances in design, measurement, and statistics are often difficult to convey to a wider research audience and considered in isolation [39]. While there has been a ...