Biginelli Reaction Catalyzed by Copper Nanoparticles

Dewan, Manika; Kumar, Ajeet; Saxena, Amit; De, Arnab; Mozumdar, Subho

doi:10.1371/journal.pone.0043078

Cited by 36 publications

(16 citation statements)

References 49 publications

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“…Our laboratory has previously used nanoparticles to catalyze a variety of reactions and synthesize many bioactive molecules 17–25. It is thus conceivable that our synthetic polymers could potentially be useful for a variety of biomedical applications.…”

Section: Discussionmentioning

confidence: 99%

Thermal properties and combustion behavior of POSS‐ and bohemite‐finished cotton fabrics

Alongi

Brancatelli²,

Rosace

2011

J of Applied Polymer Sci

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A finishing process with polyhedral oligomeric silsesquioxane (POSS) and bohemite nanoparticles has been exploited for enhancing the thermal stability and flame retardancy of cotton fabrics. The thermal behavior of flame retardant treated cellulosic fabric has been studied by thermogravimetric analyses (TGAs). It has been found that such nanoparticles favor the carbonization of the cellulose and slow down the kinetics of thermo-oxidation in air. At the same time, the finished fabrics have turned out to be more efficient with respect to neat cotton as far as the flame retardancy is concerned, pointing out an increase of the time to ignition (TTI) and a decrease of the heat release rate (HRR). Furthermore, a comparison between the fire performances of the nanoparticles under study and a commercial phosphorus-based flame retardant has been investigated. The morphology and elemental composition present in the treated fabrics have been also investigated using scanning electron microscopy (SEM) coupled to the energy dispersive spectroscopy (EDS), and the results have been compared with the untreated fabric.

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Section: Discussionmentioning

confidence: 99%

Thermal properties and combustion behavior of POSS‐ and bohemite‐finished cotton fabrics

Alongi

Brancatelli²,

Rosace

2011

J of Applied Polymer Sci

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“…Our group has reported the use of nanoparticles in biomedical applications 37,38 and catalysis [39][40][41][42][43][44][45][46][47][48][49][50][51][52] in the past. Here we have demonstrated the use of gold nanoparticles for immobilization of urease, a technique that could potentially be used to immobilize other relevant proteins and bioactive peptides.…”

Section: Resultsmentioning

confidence: 99%

pH‐dependent immobilization of urease on glutathione‐capped gold nanoparticles

Garg

Mozumdar

2014

J Biomedical Materials Res

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Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Although the enzyme serves a significant role in several detoxification and analytical processes, its usability is restricted due to high cost, availability in small amounts, instability, and a limited possibility of economic recovery from a reaction mixture. Hence, there is a need to develop an efficient, simple, and reliable immobilization strategy for the enzyme. In this study, the carboxyl terminated surface of glutathione-capped gold nanoparticles have been utilized as a solid support for the covalent attachment of urease. The immobilization has been carried out at different pH conditions so as to elucidate its effect on the immobilization efficiency and enzyme bioactivity. The binding of the enzyme has been quantitatively and qualitatively analyzed through techniques like ultraviolet-visible spectroscopy, intrinsic steady state fluorescence, and circular dichorism. The bioactivity of the immobilized enzyme was investigated with respect to the native enzyme under different thermal conditions. Recyclability and shelf life studies of the immobilized enzyme have also been carried out. Results reveal that the immobilization is most effective at pH of 7.4 followed by that in an acidic medium and is least in alkaline environment. The immobilized enzyme also exhibits enhance activity in comparison to the native form at physiological temperature. The immobilized urease (on gold glutathione nanoconjugates surface) can be effectively employed for biosensor fabrication, immunoassays and as an in vivo diagnostic tool in the future.

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“…Our laboratory has previously used nanoparticles to catalyze a variety of reactions and synthesize many bioactive molecules. [17][18][19][20][21][22][23][24][25] It is thus conceivable that our synthetic polymers could potentially be useful for a variety of biomedical applications.…”

Section: Scanning Electron Microscopymentioning

confidence: 99%

Synthesis and characterization of thermoresponsive copolymers for drug delivery

Aerry

Kumar

et al. 2012

J Biomedical Materials Res

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We report the synthesis and characterization of two nontoxic, thermogelling drug delivery systems which are liquid at room temperatures but become a gel at physiological temperature (37°C) potentially leading to release of a drug molecule. We selected temperature as the stimulus for drug release as it is physiologically invariant. A free radical polymerization of N-isopropylacrylamide (NIPAM) and N-vinylpyrrolidone (VP) was carried out under nitrogen atmosphere in double-distilled water at two different temperatures (30°C and 70°C), and the copolymers obtained were characterized by various analytical techniques. The molar ratios of the two monomers were altered with increasing NIPAM content and their cloud point temperature or least critical solution temperature (LCST) was determined. The copolymer at 9:1 ratio of NIPAM to VP resulted in the formation of nanoparticle-based gel (NG1) at 30°C; however, at 70°C, a microgel (MG1) was formed. The LCST of the nanogel and microgel was 33.5-34°C and 36.5-37°C, respectively. Thus, both the copolymers are water soluble at room temperature, but distinct phases appear at physiological temperatures. We hypothesized that these copolymers on entrapment with a drug could be used for topical application to the skin or eye for controlled drug delivery applications. Toxicological studies revealed that the copolymers are nontoxic in HeLa cells. Finally, our experiments show that a model drug [bovine serum albumin (BSA)] is released at 37°C with zero-order kinetics and confirmed using multiple well-known mathematical models.

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Biginelli Reaction Catalyzed by Copper Nanoparticles

Cited by 36 publications

References 49 publications

Thermal properties and combustion behavior of POSS‐ and bohemite‐finished cotton fabrics

Thermal properties and combustion behavior of POSS‐ and bohemite‐finished cotton fabrics

pH‐dependent immobilization of urease on glutathione‐capped gold nanoparticles

Synthesis and characterization of thermoresponsive copolymers for drug delivery

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