A k-harmonic map is a critical point of the k-energy in the space of smooth maps between two Riemannian manifolds. In this paper, we prove that if M n (n ≥ 3) is a CMC proper triharmonic hypersurface with at most three distinct principal curvatures in a space form R n+1 (c), then M has constant scalar curvature. This supports the generalized Chen's conjecture when c ≤ 0. When c = 1, we give an optimal upper bound of the mean curvature H for a non-totally umbilical proper CMC k-harmonic hypersurface with constant scalar curvature in a sphere. As an application, we give the complete classification of the 3-dimensional closed proper CMC triharmonic hypersurfaces in S 4 .