Bilateral and Extensive Xanthelasma Palpebrarum in a Young Man

Depot, Mary Jane; Dodick, Jack M.; Iwamoto, Takeo

doi:10.1016/s0161-6420(84)34260-9

Cited by 15 publications

(16 citation statements)

References 23 publications

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“…The youngest individuals can be in their first two decades of life and have family histories of xanthelasma with or without hyperlipidemia [11, 12]. Women are more often affected (over 80%) than men [13].…”

Section: Discussionmentioning

confidence: 99%

The Significance of Extracellular Cholesterol Crystals or a Cholesterol Granuloma in Xanthelasma

Wolkow

Sutula

et al. 2018

Ocul Oncol Pathol

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Background/Aims: Xanthelasma is an unreliable indicator of systemic hyperlipidemia. A review in search of unusual histopathologic features of cellular composition that might correlate with systemic hyperlipidemia was conducted. Methods: An observational case series of 3 cases was performed. Slides were stained and analyzed with hematoxylin and eosin, Masson trichrome, and periodic acid-Schiff as well as for iron. Three lesions displayed an atypical morphologic finding and were subjected to immunohistochemical analysis for CD3, CD20, CD68, CD163, S100, and adipophilin. Results: The three lesions comprised in this study had classical xanthoma cells with densely packed fine vacuoles. The xanthoma cells were CD68, CD163, and adipophilin positive and S100 negative. In case 1, extracellular, nonpolarizing cholesterol crystalloids displayed totally negative staining for all biomarkers. In cases 2 and 3, the cholesterol granulomas were surrounded and permeated by CD68- or CD163-positive epithelioid and giant cells and by CD3-positive T lymphocytes. The 3 cases each harbored squamous cysts. Conclusion: In case 1, the uninflamed extracellular cholesterol crystalloids were associated with severely dysregulated systemic hyperlipidemia. In cases 2 and 3, the cholesterol granulomas were interpreted as a local manifestation of a cyst that might have partially ruptured and did not portend serious hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

The Significance of Extracellular Cholesterol Crystals or a Cholesterol Granuloma in Xanthelasma

Wolkow

Sutula

et al. 2018

Ocul Oncol Pathol

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“…Xanthelasma is a Greek word which means yellow (xantho‐) plaque (elasma) (1). Clinically, it is a common form of cutaneous xanthomatosis, which typically involves the medial canthus and spreads frequently into the medial aspects of the upper or inferior eyelid in an arc‐like fashion.…”

Section: Introductionmentioning

confidence: 99%

“…Several unusual forms of xanthelasma have been reported, including bilateral and extensive xanthelasma and unilateral or bilateral tumor‐like invasive xanthelasma (1–4). However, no report has been issued that describes unilateral xanthelasma forming a kissing‐like lesion.…”

Section: Introductionmentioning

confidence: 99%

Unilateral Xanthelasma Forming a Kissing-Like Lesion

Bak

Park

Jeon

et al. 2005

The Journal of Dermatology

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“…De som van de scores (4-20) drukt de mate van angst uit. De gemiddelde score bij mannen bedroeg 7,5 (SD 3 ,5) en bij vrouwen 9,9 (SD 4 ,5 ) (p < 0 ,001). De 'behoeftc-aaninformatie-schaal' bestaat uit 2 vragen die elk een score van [1][2][3][4][5] kunnen krijgen.…”

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“…De som van de scores (2-10) geeft de mate van behoefte aan informatie aan. De score bedroeg bij de patiënten die eerder een operatie hadden ondergaan 6,6 (SD 2,3 ) cn bij de patiënten die deze ervaring niet hadden 7,6 (SD 2,2 ). Voorts bleek dat patiënten met een grote behoefte aan informatie ook een hoog angstniveau hadden.…”

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