Bilateral and Simultaneous Central Retinal Vein Occlusion in a Patient with Obstructive Sleep Apnea Syndrome

Abstract

Purpose: To describe a case of bilateral and simultaneous central retinal vein occlusion (RVO) in a young patient diagnosed with obstructive sleep apnea syndrome (OSAS). Case Report: A 38-year-old man with morbid obesity and daytime sleepiness presented with a history of bilateral vision loss. His visual acuity (VA) was hand movements, and fundus examination (FE) revealed bilateral central RVO. General medical examination revealed untreated hypertension and type II respiratory failure. Laboratory tests for thrombophilia showed increased hematocrit (59%) and high levels of fibrinogen and C-reactive protein. Other causes of congenital and acquired hypercoagulability were ruled out. Pathologic polysomnography led to the diagnosis of OSAS. The patient was treated with antihypertensive drugs and continuous positive air pressure. In addition, he received intravitreal ranibizumab. At 10 months after presentation, his VA was no light perception in the right eye and hand movements in the left eye. FE revealed bilateral retinal and optic nerve atrophy, and the occurrence of a nonarteritic anterior ischemic neuropathy in the right eye was considered.

Factor VG1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

“…G4070A), or the combination of Factor V and other relative genes such as MTHFR and prothrombin . Fourth, the main clinical types of retinal vein occlusion, namely BRVO and CRVO, and other uncommon types, such as bilateral RVO, exhibit the differences or complexity of physiopathology [ 1 – 3 , 55 ]. Unfortunately, we failed to obtain the SNP data of the association between Factor V Leiden and bilateral RVO risk.…”