“…190 Local reactions at the sites of injections include pain, erythema, ecchymosis, hyperpigmentation and hypopigmentation of the overlying skin, induration and inflammatory nodules, also named ''siliconomas,'' which are sometimes resolved with dystrophic scars. 121,178,[191][192][193][194][195][196][197][198] The diagnosis is not always clinically suspected, because these reactions may develop many years after the tissue augmentation. Granulomas have also been described in the skin at the point of entry of acupuncture and venepuncture needles coated with silicone and particles of silicone have been detected in macrophages with radiographic microanalysis.…”