Bilateral atrophoderma linearis: a relationship between atrophoderma linearis Moulin and atrophoderma Pasini–Pierini?

Abstract

A 26-year-old woman presented with hyperpigmented atrophic lesions on the trunk and extremities. The lesions were probably present since birth, and the size during the patient's life varied with slow growth. However, according to the patient, the shape, color, and texture of the lesions did not change during her lifetime. Her family and medical history were unremarkable. Because of the suspicion of scleroderma suggested by her family doctor, she decided to visit a dermatologist.Dermatological examination revealed slightly depressed, band-like, hyperpigmented lesions arranged bilaterally and partially symmetric in a linear configuration over the trunk as well as upper and lower extremities (Fig. 1). The lesions on the left side of the trunk and on the left upper limb were more extensive and visible. Furthermore, over the palmar side of the wrist, metacarpus, and fourth finger, the same band-like hyperpigmented lesions were also noticed. Some atrophic, hyperpigmented lesions with sharp, irregular borders were located on the chin. Physical examination as well ophthalmological and neurological consultations were unremarkable. The laboratory tests, including erythrocyte sedimentation rate, full blood count, urinalysis, and biochemical parameters, were within normal limits. Antinuclear antibodies of the granular fluorescence pattern and titer of 160 were detected with indirect immunofluorescence on HEp-2 cells. The histopathologic ª

Atrophodermia Pasini‐Pierini entlang der Blaschko‐Linien

“…Ihre Beschreibung umfasst klassischerweise einseitige, atrophische und hyperpigmentierte, nicht progressive Plaques entlang den Blaschko-Linien. Histologisch zeigen Epidermis und Dermis eine normale Dicke ohne Entzündung und Fibrose; die beobachtete Atrophie ist auf eine Verringerung des Unterhautgewebes zurückzuführen [6]. Es gab viele Veröffentlichungen über Atrophodermie in einer Blaschkolineären Verteilung mit sehr unterschiedlichen klinischen und histopathologischen Befunden.…”

“…Es gibt nur wenige Veröffentlichungen über Atrophodermie, die in einem linearen Muster auftritt und deren histologische Befunde auf die AIPP hinweisen [4,6,7,10]…”