Bilateral Atypical Femur Fracture after Prolonged Use of Alendronate - A Case Report

Schwartsmann, Carlos Roberto

doi:10.15406/mojor.2017.09.00367

Cited by 1 publication

(2 citation statements)

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“…[15][16][17] Bilateral atypical femur fractures have been reported in up to 48% of cases. [18][19][20][21][22] Cortical thickening near the fracture site and delayed union after surgical repair have also been reported. 17,[23][24][25] A taskforce committee report commissioned by the American Society for Bone and Mineral Research (ASBMR) has established definitions of the emerging phenomenon to standardize investigations into the pathophysiology, epidemiology, and orthopaedic clinical and medical management of AFFs.…”

Section: Introductionmentioning

confidence: 97%

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Health‐related quality of life outcomes after surgical treatment of atypical femur fractures: a multicenter retrospective cohort study

Spanyer¹,

Barber

Lands

et al. 2021

JBMR Plus

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The objective of this study was to examine the health-related quality of life (HRQOL) outcomes for surgically-treated atypical femur fractures (AFFs) compared to typical femoral diaphyseal fractures. Two large trauma center databases were retrospectively queried for surgically-treated femur fractures. Fractures were grouped into AFFs and compared to a control cohort. Controls for the AFF group included women with diaphyseal fractures without additional AFF characteristics. Patients were contacted for administration of the Short Form-36v2 Health Survey. Surveys were completed an average of 30.3 months (range 6-138 months) and 25.5 months (range 5-77 months) postoperatively for the AFF and non-AFF groups, respectively. All patients were female, with 46 patients in the AFF and 26 patients in the non-AFF group. The average age of the AFF group was 70.1 years compared with an average age of 67.4 years in the non-AFF group (p=0.287). 91.3% of patients in the AFF group had a history of bisphosphonate use while 26.9% of patients in the non-AFF group had used bisphosphonates (p<0.0001). Patients with AFF reported their postoperative physical and mental health to be no different than similarly aged patients with femoral diaphyseal fractures, as measured by the SF-36v2 Health Survey. These data suggest that mid-term patient-reported quality of life outcomes are similar among women who sustain an AFF compared to a cohort of more typical femoral diaphyseal fractures.

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Section: Introductionmentioning

confidence: 97%

“…( 15–17 ) Bilateral AFFs have been reported in up to 48% of cases. ( 18–22 ) Cortical thickening near the fracture site and delayed union after surgical repair have also been reported. ( 17,23–25 )…”

Section: Introductionmentioning

confidence: 99%