Bilateral bisphosphonate-related osteonecrosis of the jaw with left chronic infection in an 82-year-old woman

Gallay, Laure; Bodard, Anne-Gaëlle; Chidiac, Christian; Ferry, Tristan

doi:10.1136/bcr-2013-008558

Cited by 5 publications

(6 citation statements)

References 4 publications

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“…The latter may facilitate Actinomyces colonization and invasion of the jaw, as Actinomyces spp. have been detected in biofilm in bone samples from patients with BONJ 53,54…”

Section: Clinical Features Of Actinomycosismentioning

confidence: 99%

Actinomycosis: etiology, clinical features, diagnosis, treatment, and management

Valour¹,

Sénéchal²,

Dupieux³

et al. 2014

IDR

385

457

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Actinomycosis is a rare chronic disease caused by Actinomyces spp., anaerobic Gram-positive bacteria that normally colonize the human mouth and digestive and genital tracts. Physicians must be aware of typical clinical presentations (such as cervicofacial actinomycosis following dental focus of infection, pelvic actinomycosis in women with an intrauterine device, and pulmonary actinomycosis in smokers with poor dental hygiene), but also that actinomycosis may mimic the malignancy process in various anatomical sites. Bacterial cultures and pathology are the cornerstone of diagnosis, but particular conditions are required in order to get the correct diagnosis. Prolonged bacterial cultures in anaerobic conditions are necessary to identify the bacterium and typical microscopic findings include necrosis with yellowish sulfur granules and filamentous Gram-positive fungal-like pathogens. Patients with actinomycosis require prolonged (6- to 12-month) high doses (to facilitate the drug penetration in abscess and in infected tissues) of penicillin G or amoxicillin, but the duration of antimicrobial therapy could probably be shortened to 3 months in patients in whom optimal surgical resection of infected tissues has been performed. Preventive measures, such as reduction of alcohol abuse and improvement of dental hygiene, may limit occurrence of pulmonary, cervicofacial, and central nervous system actinomycosis. In women, intrauterine devices must be changed every 5 years in order to limit the occurrence of pelvic actinomycosis.

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“…The latter may facilitate Actinomyces colonization and invasion of the jaw, as Actinomyces spp. have been detected in biofilm in bone samples from patients with BONJ 53,54…”

Section: Clinical Features Of Actinomycosismentioning

confidence: 99%

Actinomycosis: etiology, clinical features, diagnosis, treatment, and management

Valour¹,

Sénéchal²,

Dupieux³

et al. 2014

IDR

385

457

View full text Add to dashboard Cite

show abstract

“…Actinomyces species have been implicated in two other cervicofacial pathologies, that were previously considered non-infectious diseases: bisphosphonate osteonecrosis of the jaw and osteoradionecrosis [5,19,49,50,51,52]. In both cases, Actinomyces spp.…”

Section: Epidemiology Clinical Presentationmentioning

confidence: 99%

“…and biofilm containing sulfur granules were detected in necrotic bone lesions, presumably further facilitating bone tissue damage. Radiation therapy is characterized by mucosal disruption and corticosteroid use, while bisphosphonate therapy in elderly patients is due to osteoporosis; both clinical situations usually correspond to patients with advanced age and severe underlying conditions, and these medical interventions may additionally facilitate the invasion of the jawbone by these pathogens (although the exact pathomechanism of these diseases is still not clear) [5,19,49,50,51,52].…”

Section: Epidemiology Clinical Presentationmentioning

confidence: 99%

Microbiological and Clinical Aspects of Cervicofacial Actinomyces Infections: An Overview

2019

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Similarly to other non-spore-forming Gram-positive anaerobes, members of the Actinomyces genus are important saprophytic constituents of the normal microbiota of humans. Actinomyces infections are considered to be rare, with cervicofacial infections (also known as ‘lumpy jaw syndrome’) being the most prevalent type in the clinical practice. Actinomycoses are characterized by a slowly progressing (indolent) infection, with non-specific symptoms, and additionally, the clinical presentation of the signs/symptoms can mimic other pathologies, such as solid tumors, active Mycobacterium tuberculosis infections, nocardiosis, fungal infections, infarctions, and so on. The clinical diagnosis of actinomycosis may be difficult due to its non-specific symptoms and the fastidious, slow-growing nature of the pathogens, requiring an anaerobic atmosphere for primary isolation. Based on 111 references, the aim of this review is to summarize current advances regarding the clinical features, diagnostics, and therapy of cervicofacial Actinomyces infections and act as a paper for dentistry specialists, other physicians, and clinical microbiologists.

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“…De acuerdo a la literatura ONMRB afecta principalmente a personas mayores de 60 años de edad y a las mujeres con más frecuencia que a los hombres. Las enfermedades que con mayor frecuencia subyacen ONMRB es mieloma múltiple en primer lugar, a continuación, en orden de frecuencia, cáncer de mama, cáncer de próstata y la osteoporosis (37,38,39) y la terapia prolongada BPs también se han asociado con un mayor riesgo de ONMRB (21). La epidemiología no es clara, y la incidencia reportada varía ampliamente.…”

Section: Epidemiologíaunclassified

Bifosfonatos por vía oral: consideraciones en el área odontológica

2015

SALUD MIL

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En 1995, la Food and Drug Administration (FDA) aprobó el primer bifosfonato (BP). Los bifosfonatos (BPs) comprenden una clase de fármacos que actúan sobre el metabolismo óseo, sobre todo debido a su fácil y rápida combinación con los iones minerales, especialmente el calcio.Sin embargo, los bifosfonatos (BPs) fueron sintetizados por primera vez en Alemania en 1865 (1).Con el fin de adoptar una postura y discutir acerca de los BPs, sus indicaciones, contraindicaciones y consecuen-

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Bilateral bisphosphonate-related osteonecrosis of the jaw with left chronic infection in an 82-year-old woman

Cited by 5 publications

References 4 publications

Actinomycosis: etiology, clinical features, diagnosis, treatment, and management

Actinomycosis: etiology, clinical features, diagnosis, treatment, and management

Microbiological and Clinical Aspects of Cervicofacial Actinomyces Infections: An Overview

Bifosfonatos por vía oral: consideraciones en el área odontológica

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