Bilateral Breast Cancer and Peutz-Jeghers Syndrome

Liñán, Miguel Ángel Lorenzo; Campos, Miguel Lorenzo; Micó, J.M. Adriá; Pérez, C.; Puchol, Verónica Gumbau

doi:10.1016/j.cireng.2013.07.017

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…According to the results of multiple regression analysis and published studies [22] – [28] , the risk factors for sBBC could be regarded as three aspects of the host-carcinoma biological relationship, including the tumor microenvironment, tumor cells, and genetic susceptibility.…”

Section: Discussionmentioning

confidence: 99%

“…A reasonable explanation for this discrepancy was the relatively close relationship between family history and genetic susceptibility; patients who carry a mutation in BRCA-1 or BRCA-2 may be associated with an increased risk of bilateral carcinoma [26] . In addition, genetic syndromes such as Cowden [27] , Peutz-Jeghers [28] , Li-Fraumeni [29] , and Kindler syndrome [30] may also increase the incidence of BBC.…”

Section: Discussionmentioning

confidence: 99%

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A Clinicopathological Study of Early-Stage Synchronous Bilateral Breast Cancer: A Retrospective Evaluation and Prospective Validation of Potential Risk Factors

et al. 2014

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BackgroundThe aim of the present study was to investigate potential risk factors for synchronous bilateral breast cancer sBBC).MethodsA retrospective analysis was performed of patients diagnosed and treated with operable bilateral breast cancer (BBC) between June 2007 and December 2011. Risk factors for sBBC were evaluated in this cohort and further validated in a prospective observational validation analysis of patients between January 2012 and December 2012. Patients treated with operable unilateral breast cancer during the same period were used as a control group.ResultsA total of 11,247 patients with primary breast cancer underwent operations at the Fudan University Shanghai Cancer Center between June 2007 and December 2012. The incidence of sBBC was 1.6%. The age at diagnosis (HR = 2.4, 95% C.I.: 1.4–4.0, p = 0.001), presence of sclerosing adenosis (HR = 11.8, 95% C.I.: 5.3–26.3, p<0.001), lobular carcinoma component involvement (HR = 5.6, 95% C.I.: 2.6–12.1, p<0.001), and family history of first-degree relatives with breast cancer (HR = 2.0, 95% C.I.: 1.1–3.4, p<0.001) were independent risk factors for sBBC. A subsequent validation study failed to confirm the significance of family history. No significant difference on survival was found between patients with early-stage sBBC and control cases.ConclusionsPatients with the presence of sclerosing in the affected breast, and lobular carcinoma component involvement may be at high risk for developing sBBC. This study supports the hypothesis that the host-carcinoma biological relationship, especially for the tumor microenvironment, played a critical role in the carcinogenesis of sBBC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Clinicopathological Study of Early-Stage Synchronous Bilateral Breast Cancer: A Retrospective Evaluation and Prospective Validation of Potential Risk Factors

et al. 2014

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“…Tumors usually appear at a mean age of 41.5 years, with a higher risk in females than in males (22-fold increase) and a 20% risk of any cancer by the age of 40 compared to the general population [80][81][82] . In women with germline STK11 gene mutations, the risk of BC by age 40 is 31% 83 .…”

Section: Stk11mentioning

confidence: 99%

Molecular Biology In Young Women With Breast Cancer: From Tumor Gene Expression To Dna Mutations

Gómez-Flores-Ramos¹,

Castro-Sánchez

Peña-Curiel

et al. 2017

RIC

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Young women with breast cancer (YWBC) represent roughly 15% of breast cancer (BC) cases in Latin America and other developing regions. Breast tumors occurring at an early age are more aggressive and have an overall worse prognosis compared to breast tumors in postmenopausal women. The expression of relevant proliferation biomarkers such as endocrine receptors and human epidermal growth factor receptor 2 appears to be unique in YWBC. Moreover, histopathological, molecular, genetic, and genomic studies have shown that YWBC exhibit a higher frequency of aggressive subtypes, differential tumor gene expression, increased genetic susceptibility, and specific genomic signatures, compared to older women with BC. This article reviews the current knowledge on tumor biology and genomic signatures in YWBC.

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Bilateral Breast Cancer and Peutz-Jeghers Syndrome

Cited by 2 publications

References 8 publications

A Clinicopathological Study of Early-Stage Synchronous Bilateral Breast Cancer: A Retrospective Evaluation and Prospective Validation of Potential Risk Factors

A Clinicopathological Study of Early-Stage Synchronous Bilateral Breast Cancer: A Retrospective Evaluation and Prospective Validation of Potential Risk Factors

Molecular Biology In Young Women With Breast Cancer: From Tumor Gene Expression To Dna Mutations

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