Bilateral carotid body tumor resection in a female patient

Burgess, Alfred; Calderon, Moises; Cojab, Marcos Jafif; Jorge, Diego Leonardo; Balanzá, Ricardo

doi:10.1016/j.ijscr.2017.11.019

Cited by 17 publications

(10 citation statements)

References 18 publications

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“…2,3 The onset of CBTs is sporadic, usually occurring at 40-60 years of age in women, among whom CBTs are more prevalent. While most cases are sporadic, 15% are familial or proliferative when associated with chronic hypoxia (CH), 4,5 and most are unilateral, benign masses. 6,7 Because CBT is rare, most studies have been case reports or single-center treatment experience summaries.…”

Section: Introductionmentioning

confidence: 99%

Proteomics analysis of carotid body tumor revealed potential mechanisms and molecular differences among Shamblin classifications

Lv,

Gu,

Zeng

et al. 2023

Exp Biol Med (Maywood)

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Carotid body tumors (CBTs) are a rare type of paraganglioma, and surgical resection is the only effective treatment. Because of the proximity of CBTs to the carotid artery, jugular vein, and cranial nerve, surgery is extremely difficult, with high risks of hemorrhage and neurovascular injury. The Shamblin classification is used for CBT clinical evaluation; however, molecular mechanisms underlying classification differences remain unclear. This study aimed to investigate pathogenic mechanisms and molecular differences between CBT types. In Shamblin I, II, and III tumors, differentially expressed proteins (DEPs) were identified using direct data-independent acquisition (DIA). DEPs were validated using immunohistochemistry. Proteomics profiling of three Shamblin subtypes differed significantly. Bioinformatics analysis showed that adrenomedullin signaling, protein kinase A signaling, vascular endothelial growth factor (VEGF) signaling, ephrin receptor signaling, gap junction signaling, interleukin (IL)-1 signaling, actin cytoskeleton signaling, endothelin-1 signaling, angiopoietin signaling, peroxisome proliferator–activated receptor (PPAR) signaling, bone morphogenetic protein (BMP) signaling, hypoxia-inducible factor 1-alpha (HIF-1α) signaling, and IL-6 signaling pathways were significantly enriched. Furthermore, 60 DEPs changed significantly with tumor progression. Immunohistochemistry validated several important DEPs, including aldehyde oxidase 1 (AOX1), mediator complex subunit 22 (MED22), carnitine palmitoyltransferase 1A (CPT1A), and heat shock transcription factor 1 (HSF1). To our knowledge, this is the first application of proteomics quantification in CBT. Our results will deepen the understanding of CBT-related pathogenesis and aid in identifying therapeutic targets for CBT treatment.

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Section: Introductionmentioning

confidence: 99%

Proteomics analysis of carotid body tumor revealed potential mechanisms and molecular differences among Shamblin classifications

Lv,

Gu,

Zeng

et al. 2023

Exp Biol Med (Maywood)

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“…Gross total resection (GTR) is the gold standard for resectable CBTs in healthy patients due to risks of damage to local structures and risk of metastatic disease if left untreated ( Burgess et al 2017 ). Complete tumor regression with RT or chemotherapy alone is rare ( Mendenhall et al 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Paragangliomas of the head and neck: a contemporary review

et al. 2022

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Head and neck paragangliomas are slow-growing, vascular, typically benign tumors whose growth may induce significant lower cranial nerve deficits. While most tumors arise sporadically, a significant portion are associated with defined genetic syndromes. While surgical resection has historically been the gold standard, management strategies have evolved with acknowledgement of high surgical morbidity, slow tumor growth rates, and technological advances. Conservative management approaches via observation and newer radiation therapy techniques have become more common. This review seeks to provide an update on contemporary management strategies for head and neck paragangliomas and future directions.

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“…La incidencia de los TCC se ha descrito aproximadamente en 1 de cada 30,000-100,000 habitantes, por lo que las neoplasias son poco comunes, sin embargo, representan más de la mitad de los paragangliomas que corresponden a la zona de cabeza y cuello 2 . Nueve de cada diez casos ocurren esporádicamente, el resto son hereditarios, en donde se han reportado cerca de 1/3 de TCC bilaterales (menos del 5% del total de casos) 5,6 . Se han identificado alrededor de seis genes asociados al posible desarrollo de feocromocitomas/paragangliomas 4 .…”

Section: Introductionunclassified

Utilidad de la volumetría de los tumores del cuerpo carotídeo como predictor de sangrado transoperatorio y tiempo quirúrgico

García-Alva¹,

López-Peña²,

Ricárdez³

et al. 2022

RMA

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Determinar la asociación entre volumetría en centímetros cúbicos (cm 3 ) y el sangrado durante la resección quirúrgica de los tumores del cuerpo carotídeo. Antecedentes: Los tumores del cuerpo carotídeo son paragangliomas localizados en la región cervical. La incidencia de estos tumores es de 1 en 30,000 a 100,000 personas en la población general. El tratamiento de elección es la resección quirúrgica, estos tumores se han relacionado a un importante sangrado. Métodos: Prospectivo, se realizó la medición de la volumetría (cm 3 ) prequirúrgica por medio de angiotomografía. Usamos prueba de Spearman para la correlación entre volumen, sangrado transquirúrgico y tiempo quirúrgico. Resultado: Se identificaron 29 pacientes en el período de tiempo de marzo de 2017 a abril de 2019. El 86% de los pacientes fueron mujeres, la media de edad fue de 55 años; el 52% fueron tumores derechos, el 34%, izquierdos y el 14%, bilaterales. La mediana de la volumetría de los tumores fue de 17 cm 3 y la mediana de sangrado transoperatorio fue de 300 ml. En la prueba de Spearman se encontró una r = 0.426; p = 0.021. Conclusiones: La medición de la volumetría por angiotomografía de los tumores del cuerpo carotídeo puede ser utilizada como predictor de sangrado durante la resección quirúrgica.

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Bilateral carotid body tumor resection in a female patient

Abstract: HighlightsCarotid body tumors are rare neuroendocrine neoplasms derived from neural crest cells.MRI imaging is considered to be the gold standard criterion for carotid body tumors diagnosis.Surgical resection of carotid body tumors represents a special challenge to the surgeon.

Cited by 17 publications

References 18 publications

Proteomics analysis of carotid body tumor revealed potential mechanisms and molecular differences among Shamblin classifications

Proteomics analysis of carotid body tumor revealed potential mechanisms and molecular differences among Shamblin classifications

Paragangliomas of the head and neck: a contemporary review

Utilidad de la volumetría de los tumores del cuerpo carotídeo como predictor de sangrado transoperatorio y tiempo quirúrgico

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