Bilateral carpal tunnel syndrome in childhood

Starreveld, Elout; Ashenhurst, Edward M.

doi:10.1212/wnl.25.3.234

Cited by 29 publications

(5 citation statements)

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“…Bilateral involvement is seen in about 50% of cases, 29 and fewer than 1% of patients have onset before the age of 20 years. 3,20,23 CTS is also seen with repetitive use or traumatic injury, 23 as a component of polyneuropathies, 27 and in systemic disorders such as the mucolipidoses, mucopolysaccharidoses, 3,11,22,28 and osteochondritis dissecans. …”

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confidence: 99%

Is there a familial carpal tunnel syndrome? An evaluation and literature review

Gossett

Chance

1998

Muscle Nerve

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confidence: 99%

Is there a familial carpal tunnel syndrome? An evaluation and literature review

Gossett

Chance

1998

Muscle Nerve

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“…,~* ,~~ This clinical picture may be the first indication of occult MPS/ML." 48 Although CTS is a common cause of thenar atrophy in the adult, in children, a smaller than normal thenar eminence may be secondary to congenital thenar hypoplasia. 7 We have seen 1 such adolescent not reported in this study.…”

Section: Discussionmentioning

confidence: 99%

Pediatric median mononeuropathies: A clinical and electromyographic study

Deymeer

1994

Muscle and Nerve

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Seventeen children, 6 girls and 11 boys, aged 5-17 years with pediatric median mononeuropathies (PMM) were identified among 1809 who had EMGs primarily in the electromyographic laboratory at The Children's Hospital, Boston, between 1979 and 1993. Electromyography documented the PMM to be at the wrist in 7 children, including 3 children with idiopathic carpal tunnel syndrome (CTS)--1 whose symptoms were accentuated by skiing--2 with a systemic illness (mucolipidosis III and scleroderma), and in 1 child each the distal PMM was secondary to a cast or laceration. A proximal PMM was identified in 10 children, including 8 with trauma, 1 with an osteoid osteoma, and 1 with juvenile cutaneous mucinosis. Five children (3 with CTS and 1 each with mucolipidosis III and juvenile cutaneous mucinosis) had bilateral disease. The localization (59% proximal) and cause of these PMMs differed greatly from our experience with adult median neuropathies.

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“…Though the clinical features vary widely within the groups, musculoskeletal involvement is similar and is the earliest and common feature with which patients present [5]. CTS has been reported by many studies in association with MPS I, MPS II (Hunter syndrome), MPS VI, ML II and ML III [6,7,8,9,10,11]. …”

Section: Introductionmentioning

confidence: 99%

Bilateral Carpal Tunnel Syndrome in Two Children: Common Manifestation of an Uncommon Disease

Sharma

Ramachandran²,

Bhat³

et al. 2013

Pediatr Neurosurg

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Carpal tunnel syndrome (CTS) is a rare entity in children and usually has a different clinical presentation than in adults. The majority of these cases are related to a genetic condition. The most common aetiology is a lysosomal storage disease such as mucopolysaccharidoses or mucolipidoses (ML). Two siblings with bilateral median nerve neuropathy, wrist contractures and skeletal deformity on a background of mild facial coarsening and normal cognition are presented. There was a family history of similar complaints in first cousins. Nerve conduction studies were suggestive of bilateral median neuropathy with conduction block at the wrists. Biochemical investigation showed high levels of plasma lysosomal enzymes. Both patients underwent bilateral flexor retinaculum release. The findings at surgery were severe compression of the median nerve by the thickened flexor retinaculum. The histopathology of the thickened tissue showed a fibrosed and vascularised flexor retinaculum. On electron microscopy, macrophages with membrano-vacuolated inclusion zebra bodies were seen. Both patients had an uneventful recovery with symptomatic improvement. CTS is rarely seen in children except in association with genetic disorders. There is usually a delay in the diagnosis as attention is paid to the contractures rather than to the median nerve compression. The presence of CTS is typically seen in ML types II and III. Surgical intervention helps in improving the quality of life and hand function of these patients.

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Bilateral carpal tunnel syndrome in childhood

Cited by 29 publications

References 0 publications

Is there a familial carpal tunnel syndrome? An evaluation and literature review

Is there a familial carpal tunnel syndrome? An evaluation and literature review

Pediatric median mononeuropathies: A clinical and electromyographic study

Bilateral Carpal Tunnel Syndrome in Two Children: Common Manifestation of an Uncommon Disease

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