“…[1][2][3][4][5][6][7] However, it is still unknown whether it is better for these patients to have ISCS or delayed sequential cataract surgery (DSCS). Despite the obvious benefits of ISCS to patients and society, [8][9][10][11] the major reluctance of ophthalmologists to perform ISCS revolves to some extent around its non-catastrophic complications, such as refractive surprises, and most importantly, its catastrophic complications, such as endophthalmitis, 11 especially due to contaminated instrument-derived incidents; 12 however, the literature indicates that the safety of ISCS has been increasing, 1,[13][14][15][16][17] particularly with recent advancements of microsurgical techniques 18,19 and the use of strict protocols for post-operative endophthalmitis prophylaxis. 20 Furthermore, if an intraoperative complication occurs during the first-eye surgery, surgery for the second eye can be aborted.…”