Bilateral changes in excitability of sensorimotor cortices during unilateral movement: Combined electroencephalographic and transcranial magnetic stimulation study

Kičić, Dubravko; Lioumis, Pantelis; Ilmoniemi, Risto J.; Nikulin, Vadim V.

doi:10.1016/j.neuroscience.2008.01.043

Cited by 67 publications

(62 citation statements)

References 77 publications

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“…The amplitude of the different TEP components may be influenced by numerous factors, such as a decrease in N100 amplitude when preparing a voluntary movement (Kičić et al 2008;). However, it is possible that observed variations in N100 or P180 partly reflect variations in auditory processing in addition to a TMS effect, and therefore N100 and P180 (and perhaps even P60) modulation should be used carefully as an outcome measure when no masking or a non-sufficient masking method is used.…”

Section: Discussionmentioning

confidence: 99%

“…The N100 has been related to inhibitory circuits (Casula et al 2014;Kičić et al 2008;: an increase in N100 reflects an increase in inhibition. A previous study in EPM1 patients showed a higher amplitude of the P30 and a lower amplitude of the N100 and P180 compared to healthy controls ).…”

Section: Discussionmentioning

confidence: 99%

“…The N15-P30 complex shows a correlation with the amplitude of the motor evoked potential and probably reflects excitation . On the other hand, the N100 is strongly related to inhibitory processes, with a reduction in amplitude when a subject is preparing for a movement (Kičić et al 2008;. The N100 correlates with the duration of the CSP ).…”

Section: Introductionmentioning

confidence: 99%

“…The TEP has shown to be reproducible within a one-week interval ) and changes shape when different parts of the cortex are stimulated ). The physiological processes responsible for the different components are still largely unknown , although some studies suggested that the N100 reflects cortical inhibitory processes (Kičić et al 2008;. The variation in the amplitude of the motor evoked potential (MEP) has also been shown to correspond to variations in the amplitude of earlier TEP peaks (N15 and P30) .…”

Section: Introductionmentioning

confidence: 99%

“…In some studies, earplugs alone (Julkunen et al 2008;Kähkönen et al 2001;Kähkönen et al 2005a;Kähkönen et al 2005b), or a combination of earplugs with an earmuff (Bikmullina et al 2009;Kičić et al 2008;, have been used. Other studies report the administration of sound through (regular or inserted) headphones to make sure that the subject does not hear the TMS click.…”

Section: Introductionmentioning

confidence: 99%

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TMS-EEG: first steps towards a clinical application in epilepsy

Braack¹,

Esther²

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1) A parameter that is robust only when using a very strict measuring protocol, cannot be used in clinical practice2) Complete understanding of the TEP is not necessary for clinical utility 3) A silent TMS coil is required for optimal N100/P180 evaluation 4) Defining TMS as a non-invasive technique is inexplicable5) The search for significant differences has nothing to do with clinically relevant findings 6) Progress would be faster if scientists would share more with each other 7) Technology develops faster than our ability to adequately use it 8) There is an important task for the Technical Physician in the medical device industry 9) Life is what happens to us, while we are making other plans (Allen Saunders)Esther ter Braack 6 June 2018 StellingenBehorende bij het proefschrift TMS-EEG: first steps towards a clinical application in epilepsy 1) Een meetrespons die alleen robuust is met een zeer sterk gecontroleerd meetprotocol, is niet bruikbaar in de klinische praktijk 2) Volledig begrip van de TEP is niet vereist voor klinisch gebruik 3) Een stille TMS spoel is nodig voor optimale N100/P180 evaluatie 4) TMS definiëren als een niet-invasieve techniek is niet uit te leggen 5) De zoektocht naar significante verschillen heeft niets te maken met klinisch relevante resultaten 6) De vooruitgang zou sneller gaan als wetenschappers meer met elkaar zouden delen 7) Technologie ontwikkelt zich sneller dan ons vermogen om deze adequaat te gebruiken 8) Er ligt een belangrijke taak voor de Technisch Geneeskundige in de medische technologie industrie 9) Het leven is wat ons overkomt, terwijl we andere plannen maken (Allen Saunders)Esther ter Braack 6 juni 2018 In all patients, evaluation of AED success is based on the absence or recurrence of the seizures, so during this trial and error based process additional seizures may occur. It can take up to several months to either achieve an effective dosage and/or combination of AEDs, meaning that the patient becomes seizure free; or conclude that the patient suffers from refractory epilepsy. Hence, a major challenge is to shorten the time needed to evaluate the success of AEDs on a single subject level. TMS-EEG: FIRST STEPS TOWARDS A CLINICAL APPLICATION IN EPILEPSY ESTHER M. TER BRAACKIn patients with only one seizure, and a normal EEG and MRI, uncertainty remains. A seizure is a traumatic experience, and an epilepsy diagnosis has potential serious consequences, such as the loss of a driving licence or the need for career changes.Currently there is only one option in these patients: wait if a second seizure occurs. The estimated probability of seizure recurrence in patients with a normal EEG is 27.4% (Krumholz et al. 2007). This means that more than a quarter of these patients do have epilepsy, but the definite diagnosis is made only at a later stage. Therefore, another major challenge is to improve the diagnostic process in patients who present with a single seizure and a normal EEG and MRI scan.When we consider these two major challenges, namely improving diagnostics and short...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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TMS-EEG: first steps towards a clinical application in epilepsy

Braack¹,

Esther²

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Tms‐eeg

Kallioniemi¹,

Könönen²,

Määttä³

2018

Biomedical Engineering Challenges

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Reproducibility of TMS—Evoked EEG responses

Lioumis

Kičić²,

Savolainen

et al. 2008

Human Brain Mapping

269

239

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Navigated transcranial magnetic stimulation combined with electroencephalography (nTMS-EEG), allows noninvasive studies of cortical excitability and connectivity in humans. We investigated the reproducibility of nTMS-EEG in seven healthy subjects by repeating left motor and prefrontal cortical stimulation with a 1-week interval. TMS was applied at three intensities: 90, 100, and 110% of subjects' motor threshold (MT). The TMS-compatible neuronavigation system guaranteed precise repositioning of the stimulation coil. The responses were recorded by a 60-channel whole head TMS-compatible EEG amplifier. A high overall reproducibility (r > 0.80) was evident in nTMS-EEG responses over both hemispheres for both motor and prefrontal cortical stimulation. The results suggest that nTMS-EEG is a reliable tool for studies investigating cortical excitability changes in the test-retest designs.

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Bilateral changes in excitability of sensorimotor cortices during unilateral movement: Combined electroencephalographic and transcranial magnetic stimulation study

Cited by 67 publications

References 77 publications

TMS-EEG: first steps towards a clinical application in epilepsy

TMS-EEG: first steps towards a clinical application in epilepsy

Tms‐eeg

Reproducibility of TMS—Evoked EEG responses

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