Bilateral DMPFC-RTMS Leads to Sustained Remission in Geriatric Treatment-Resistant Depression: A Case Report

Sender, David; Nazar, Bruno Palazzo; Baczynski, Tathiana Pires; Paes, Flávia; Fettes, Peter; Downar, Jonathan; Campos, Carlos Eduardo Aguilera; Nardi, Antônio Egídio; Machado, Sérgio

doi:10.24869/psyd.2017.218

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…New advances in neuroimaging studies of depression, MRI‐guided rTMS, as well as the introduction of coils with the capacity to stimulate deep structures, have helped improve the identification of optimal stimulation sites. rTMS targeting other core regions whose connectivity has been shown to be disrupted in depression such as the DMPFC, OFC, ACC, has demonstrated apparent therapeutic effectiveness. Although commonly applied to single brain regions, the effects of DBS and TMS are mediated via distributed networks.…”

Section: Brain Connectivity and Treatment Of Depressionmentioning

confidence: 99%

A brain network model for depression: From symptom understanding to disease intervention

et al. 2018

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Understanding the neural substrates of depression is crucial for diagnosis and treatment. Here, we review recent studies of functional and effective connectivity in depression, in terms of functional integration in the brain. Findings from these studies, including our own, point to the involvement of at least four networks in patients with depression. Elevated connectivity of a ventral limbic affective network appears to be associated with excessive negative mood (dysphoria) in the patients; decreased connectivity of a frontal-striatal reward network has been suggested to account for loss of interest, motivation, and pleasure (anhedonia); enhanced default mode network connectivity seems to be associated with depressive rumination; and diminished connectivity of a dorsal cognitive control network is thought to underlie cognitive deficits especially ineffective top-down control of negative thoughts and emotions in depressed patients. Moreover, the restoration of connectivity of these networks-and corresponding symptom improvement-following antidepressant treatment (including medication, psychotherapy, and brain stimulation techniques) serves as evidence for the crucial role of these networks in the pathophysiology of depression.

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Section: Brain Connectivity and Treatment Of Depressionmentioning

confidence: 99%

A brain network model for depression: From symptom understanding to disease intervention

et al. 2018

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“…2,8 Sender and Nazar (2017) study' described a case report for the functional improvement of an SIB sufferer's right hand. 9 In this case, according to the surgical opinion, further delay in presentation to psychiatric services could have led to far more serious damage to the patient's finger culminating in possible amputation. Generally, the prevalence of challenging behaviour increases with age until early adulthood, and it once manifests, SIB is likely to continue over the patient's lifespan, is resistant to treatment, and costly to treat.…”

Section: Discussionmentioning

confidence: 92%

Introducing a New Nursing Intervention Developed for Self-Injury Behaviour in Children with Intellectual Disabilities

Teksöz¹

2019

Turkiye Klinikleri J Nurs Sci

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ntellectual disabilities (ID) are characterized by violent outbursts of anger and stereotypical or self-injurious behaviour (SIB). 1,2 ID affects approximately 1% of the population and sufferers are at increased risk for SIB which is one of the most striking and devastating conditions associated with ID, and tends to affect children over 3. 2-4 The prevalence of SIB is growing and is highest in young children referred to neurodevelopmental paediatric clinics. 5,6 The most commonly used definition of SIB are acts directed toward oneself that are likely to result in tissue damage. There are varying types of SIB. The most common forms associated with ID are selfbiting, head-hitting, head-banging, and excessive self-rubbing and selfscratching. 1,3,4,7 The purpose of this case report is to illustrate the successful use of an alternative, medication-free nursing interventions for a child diagnosed with ID who manifests SIB by biting his right hand; a new type of palmar bandage featuring an attached stress ball.

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“…A team of researchers from Brazil have reported sustained remission for up to five months in a 60-year-old male following 20 sessions of 10 Hz rTMS over bilateral dorsomedial PFC rTMS (DMPFC). However, local discomfort and headache were reported as adverse effects that subsided with minimal intervention (Sender et al, 2017). Philip and Carpenter (2013) have published the development of hypomanic symptoms following six sessions of five Hz rTMS over left DLPFC with 3,000 pulses per session in a 52-year-old woman, which was severe enough to stop the further sessions.…”

Section: Resultsmentioning

confidence: 99%

Transcranial Magnetic Stimulation for the treatment of late-life depression: A scoping review

Vidya¹,

Tripathi²,

Kumari³

et al. 2022

GPA

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Objective: Transcranial magnetic stimulation (TMS) is a form of neuromodulation used to treat various neuropsychiatric disorders. The clinical utility of TMS in older adults with depression is less studied. This review was conducted to compile the study findings on the efficacy and adverse effects of TMS in later-life depression to elucidate gaps in the literature and formulate recommendations. Materials and methods:A search was conducted on PubMed, Scopus and Ovid databases with search terms based on the three domains of our research questions, namely "transcranial magnetic stimulation", "depression", and "later life". All the articles published in English until June 2021 were incorporated and critically appraised after fulfilling inclusion and exclusion criteria. Results: A total of 643 articles were screened with title and abstract, and 41 were selected for full-text assessment. Finally, 26 articles were included after scrutiny and findings were tabulated. This consisted of 8 randomized controlled trials (RCTs), six open-label, one retrospective study, 4 case series and 7 case reports. Available findings in this area so far are mixed and inconclusive. Level I evidence for the use of TMS in later-life depression is lacking. Conclusion: Evidence regarding the efficacy of TMS in the treatment of depression in older adults lacks consistency in the outcomes, which warrants an urgent need for systematic review and meta-analysis of RCTs on the use of TMS in later-life depression.

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Bilateral DMPFC-RTMS Leads to Sustained Remission in Geriatric Treatment-Resistant Depression: A Case Report

Cited by 4 publications

References 14 publications

A brain network model for depression: From symptom understanding to disease intervention

A brain network model for depression: From symptom understanding to disease intervention

Introducing a New Nursing Intervention Developed for Self-Injury Behaviour in Children with Intellectual Disabilities

Transcranial Magnetic Stimulation for the treatment of late-life depression: A scoping review

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