Bilateral End-Organ Endophthalmitis in Setting of Serratia marcescens Urosepsis on 18F-FDG PET/CT

Makusha, Lovemore Peter; Young, Colin R.; Agarwal, Daniel R.; Pucar, Darko

doi:10.1097/rlu.0000000000002883

Cited by 10 publications

(12 citation statements)

References 8 publications

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“…Endophthalmitis caused by Serratia marcescens is very rare, where most of the cases progress to NLP. Most of the reported cases have a history of interventional surgery, oral surgery, and intravenous drug use [16]. Both liver abscess and endophthalmitis caused by Staphylococcus walleriae and Bacillus licheniformis are uncommon, implying they should be paid more attention in the clinics.…”

Section: Discussionmentioning

confidence: 99%

Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess

Wang

2020

BMC Infect Dis

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Backgrounds Endogenous endophthalmitis is a serious disease caused by intraocular infection that can rapidly progress to cause blindness. This study evaluated the clinical features, surgical and antibiotics treatment strategies, and treatment outcomes in patients with endophthalmitis caused by liver abscess. Methods Between April 2014 and April 2019, the clinical data of 16 patients (19 eyes) with endophthalmitis associated with liver abscess who underwent surgery at Shengjing Hospital were retrospectively analyzed. Furthermore, we evaluated the final visual outcomes in the patients to determine the efficacy of surgery. Results Fifteen patients (18 eyes) underwent intravitreal injection followed by vitrectomy after admission. One patient (1 eye) only underwent intravitreal injection. Of the 16 patients, 3 patients (3 eyes) had recurrent intraocular inflammation and eventually underwent evisceration. Systemic antibiotics were administered for all patients based on the results of vitreous humor culture, blood culture, and antibiotic susceptibility tests. Outpatient follow-ups were performed until the patients were stable (6 months). Of the 19 eyes, 1 eye (5%) had visual acuity restored to 20/200, 6 eyes (31%) had visual acuity restored to counting fingers (CF), 2 eyes (11%) had visual acuity restored to hand motion (HM), 4 eyes (22%) showed only light perception (LP), and the remaining 6 eyes (31%) showed no light perception (NLP). Drug susceptibility tests suggested that the carbapenems exhibited significant effects in the inflammatory reaction. Conclusion Endogenous endophthalmitis caused by liver abscess is a very serious condition, and the final visual outcome is poor. Timely surgical intervention combined with antibiotic treatment is essential, and the primary disease must be treated to control disease progression at the earliest.

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Section: Discussionmentioning

confidence: 99%

Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess

Wang

2020

BMC Infect Dis

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“…Most of the reported cases have a history of interventional surgery, oral surgery, and intravenous drug use. 16 Both liver abscess and endophthalmitis caused by Staphylococcus walleriae and Bacillus licheniformis are uncommon, implying they should be paid more attention in the clinics. The ideal condition for performing a bacterial culture is during the absence of antibiotic treatment following disease onset.…”

Section: Discussionmentioning

confidence: 99%

Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by live abscess

Wang

2020

Preprint

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Backgrounds: Endogenous endophthalmitis is a serious disease caused by intraocular infection that can rapidly progress to cause blindness. This study evaluated the clinical features, surgical and antibiotics treatment strategies, and treatment outcomes in patients with endophthalmitis caused by liver abscess.Methods: Between April 2014 and April 2019, the clinical data of 16 patients (19 eyes) with endophthalmitis associated with liver abscess who underwent surgery at Shengjing Hospital were retrospectively analyzed. Furthermore, we evaluated the final visual outcomes in the patients to determine the efficacy of surgery.Results: Fifteen patients (18 eyes) underwent intravitreal injection followed by vitrectomy after admission. One patient (1 eye) only underwent intravitreal injection. Of the 16 patients, 3 patients (3 eyes) had recurrent intraocular inflammation and eventually underwent evisceration. Systemic antibiotics were administered for all patients based on the results of vitreous humor culture, blood culture, and antibiotic susceptibility tests. Outpatient follow-ups were performed until the patients were stable (6 months). Of the 19 eyes, 1 eye (5%) had visual acuity restored to 20/200, 6 eyes (31%) had visual acuity restored to counting fingers (CF), 2 eyes (11%) had visual acuity restored to hand motion (HM), 4 eyes (22%) showed only light perception (LP), and the remaining 6 eyes (31%) showed no light perception (NLP). Drug susceptibility tests suggested that the carbapenems exhibited significant effects in the inflammatory reaction.Conclusion: Endogenous endophthalmitis caused by liver abscess is a very serious condition, and the final visual outcome is poor. Timely surgical intervention combined with antibiotic treatment is essential, and the primary disease must be treated to control disease progression at the earliest.

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“…[ 18 F]FDG-PET/CT is important for diagnosing persistent musculoskeletal infections [ 45 ] including the detection of chronic osteomyelitis [ 46 ] ( Figure 4 ). Some other uses of [ 18 F]FDG-PET/CT may include evaluation of the diabetic foot [ 47 ], implant-related infections in the leg [ 48 ], and septic arthritis [ 44 , 49 , 50 , 51 , 52 ].…”

Section: State Of Pet Imaging In Infectious Diseasesmentioning

confidence: 99%

Is Imaging Bacteria with PET a Realistic Option or an Illusion?

et al. 2023

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The application of [18F]-fluorodeoxyglucose ([18F]FDG) as a radiotracer to detect sites of inflammation (either due to bacterial infection or primary inflammation) has led to exploring the role of PET in visualizing bacteria directly at sites of infection. However, the results from such efforts are controversial and inconclusive so far. We aimed to assess the limitations of PET as an effective modality in the diagnosis of bacterial infections. Inflammation due to bacterial infections can be visualized by using [18F]FDG-PET. However, the non-specificity of [18F]FDG makes it undesirable to visualize bacteria as the underlying cause of inflammation. Hence, more specific radiotracers that possibly bind to or accumulate in bacteria-specific receptors or enzymes are being explored. Several radiotracers, including 2-deoxy-2-[18F]fluorosorbitol ([18F]FDS), 6-[18F]-fluoromaltose, [11C]para-aminobenzoic acid ([11C]PABA), radiolabeled trimethoprim (11C-TMP) and its analog fluoropropyl-trimethoprim (18F-FPTMP), other radiolabeled sugars, and antimicrobial drugs have been used to image microorganisms. Unfortunately, no progress has been made in translating the results to routine human use; feasibility and other factors have constrained their success in clinical settings. In the current article, we discuss the limitations of direct bacterial visualization with PET tracers, but emphasize the important role of [18F]FDG-PET as the only option for detecting evidence of infection.

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Bilateral End-Organ Endophthalmitis in Setting of Serratia marcescens Urosepsis on 18F-FDG PET/CT

Cited by 10 publications

References 8 publications

Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess

Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by liver abscess

Surgery combined with antibiotics for the treatment of endogenous endophthalmitis caused by live abscess

Is Imaging Bacteria with PET a Realistic Option or an Illusion?

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