“…In this review, 21 major and minor fetal anomalies were found including serious CNS, cardiac, renal, facial, extremity anomalies, and diaphragmatic hernias out of the 196 CD cases, with an overall incidence of 10.7%. 2,5,6,8,34,37 This finding yields that CD may not be an isolated, benign anomaly as advocated previously. However, the high overall anomaly rate needs to be interpreted cautiously because the study findings may be influenced by ascertainment bias.…”