Bilateral field advantage and evoked potential interhemispheric transmission in commissurotomy and callosal agenesis

Brown, Warren S.; Jeeves, M. A.; Dietrich, R B; Burnison, Debra S

doi:10.1016/s0028-3932(99)00011-1

Cited by 122 publications

(112 citation statements)

References 55 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Callosal fibers are important for motor and sensory integration, attention, memory, and general cognitive functioning. [10][11][12] The time course of maturation until 5 years of age as observed in our study is concordant with major psychological maturation processes: The gCC is mainly related to important interhemispheric association fibers that play a major role in several of these processes. Any disturbance or anomalies in the CC can result in certain neurologic disorders.…”

Section: Discussionsupporting

confidence: 84%

“…Any disturbance could lead to clinical impairment. [10][11][12] Despite the great interest in the development and function of interhemispheric connections, little is known about the development and organization of the tract itself. [13][14][15][16][17] Previous studies, including those of children of different age ranges, found age-dependent fractional anisotropy (FA) values.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Evidence of Rapid Ongoing Brain Development Beyond 2 Years of Age Detected by Fiber Tracking

Ding

Sun²,

Braaß³

et al. 2008

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 84%

mentioning

confidence: 99%

Evidence of Rapid Ongoing Brain Development Beyond 2 Years of Age Detected by Fiber Tracking

Ding

Sun²,

Braaß³

et al. 2008

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…This procedure is described in greater detail elsewhere (DeBoard Marion et al, 2008). IHTT is sensitive to disruptions of the CC (Brown et al, 1999;Rugg et al, 1985), as demonstrated in patients with commissurotomies, callosotomies, and callosal agenesis. Longer IHTTs indicate slower transfer of information across the posterior visual brain regions.…”

Section: Electrophysiological Measurementioning

confidence: 98%

Metabolic Levels in the Corpus Callosum and Their Structural and Behavioral Correlates after Moderate to Severe Pediatric TBI

Babikian

Marion

Copeland

et al. 2010

Journal of Neurotrauma

View full text Add to dashboard Cite

Diffuse axonal injury (DAI) secondary to traumatic brain injury (TBI) contributes to long-term functional morbidity. The corpus callosum (CC) is particularly vulnerable to this type of injury. Magnetic resonance spectroscopy (MRS) was used to characterize the metabolic status of two CC regions of interest (ROIs) (anterior and posterior), and their structural (diffusion tensor imaging; DTI) and neurobehavioral (neurocognitive functioning, bimanual coordination, and interhemispheric transfer time [IHTT]) correlates. Two groups of moderate=severe TBI patients (ages 12-18 years) were studied: post-acute (5 months post-injury; n ¼ 10), and chronic (14.7 months post-injury; n ¼ 8), in addition to 10 age-matched healthy controls. Creatine (energy metabolism) did not differ between groups across both ROIs and time points. In the TBI group, choline (membrane degeneration=in-inflammation) was elevated for both ROIs at the post-acute but not chronic period. N-acetyl aspartate (NAA) (neuronal=axonal integrity) was reduced initially for both ROIs, with partial normalization at the chronic time point. Posterior, not anterior, NAA was positively correlated with DTI fractional anisotropy (FA) (r ¼ 0.88), and most domains of neurocognition (r range 0.22-0.65), and negatively correlated with IHTT (r ¼ À0.89). Inverse corerlations were noted between creatine and posterior FA (r ¼ À0.76), neurocognition (r range À0.22 to À0.71), and IHTT (r ¼ 0.76). Multimodal studies at distinct time points in specific brain structures are necessary to delineate the course of the degenerative and reparative processes following TBI, which allows for preliminary hypotheses about the nature and course of the neural mechanisms of subsequent functional morbidity. This will help guide the future development of targeted therapeutic agents.

show abstract

“…The corpus callosum allows visual input from each visual field to activate the ipsilateral hemisphere, as normal subjects show delayed ipsilateral ERPs [19], while acallosal subjects show very little evidence of ipsilateral ERPs [2]and split-brained subjects show none [20]. It is possible, therefore, that a unilateral stimulus may result in response preparation processes being initiated in both hemispheres in callosally intact subjects, resulting in interhemispheric neural summation even for single stimuli.…”

Section: Processing Stagementioning

confidence: 99%

“…Acallosal subjects do show some visually evoked activation in the hemisphere ipsilateral to stimulation [2,34], and are often able to integrate information presented in the two visual fields [18,25]. Therefore, they may show less of a redundancy gain than split-brain subjects because they experience limited summation on single stimuli trials.…”

Section: Processing Stagementioning

confidence: 99%

Interhemispheric neural summation in the split brain: effects of stimulus colour and task

Roser

Corballis

2003

Neuropsychologia

View full text Add to dashboard Cite

Four split-brained subjects, two subjects with agenesis of the corpus callosum, and 14 normal subjects performed two tasks requiring responses to red or green disks, briefly presented either singly in the left visual field, singly in the right visual field, or simultaneously in both visual fields. In Experiment 1, simple reaction times to these stimuli, regardless of colour, were recorded (the Go-Both Task), and found to be faster to bilateral-redundant stimulus pairs, than to single stimuli. This so-called "redundancy gain" was much larger for acallosal or split-brained subjects than for normal subjects and exceeded the predictions of a race model, implying neural summation. Experiment 2 used the same stimuli, but subjects were required to respond only to stimuli of a designated colour (the Go/No-Go Task). Redundant target stimuli produced neural summation, while stimuli pairs that included a non-target stimulus did not. These results suggest that neural summation in the acallosal or split brain involves the convergence of response-associated activation, and that redundant sensory processes are not sufficient.

show abstract

Bilateral field advantage and evoked potential interhemispheric transmission in commissurotomy and callosal agenesis

Cited by 122 publications

References 55 publications

Evidence of Rapid Ongoing Brain Development Beyond 2 Years of Age Detected by Fiber Tracking

Evidence of Rapid Ongoing Brain Development Beyond 2 Years of Age Detected by Fiber Tracking

Metabolic Levels in the Corpus Callosum and Their Structural and Behavioral Correlates after Moderate to Severe Pediatric TBI

Interhemispheric neural summation in the split brain: effects of stimulus colour and task

Contact Info

Product

Resources

About