Bilateral gluteal metastases from a misdiagnosed intrapelvic gastrointestinal stromal tumor

Pasku, Dritan; Karantanas, Apostolos H.; Giannikaki, Elpida; Tzardi, Maria; Velivassakis, Emmanouil; Katonis, Pavlos

doi:10.1186/1477-7819-6-139

Cited by 16 publications

(17 citation statements)

References 18 publications

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“…Histologically, EGISTs often present as spindle cells and therefore might be excluded from the differential diagnosis of spindle cell neoplasm and could be confused with the more common leiomyoma or leiomyosarcoma [11]. Some authors reported that immunohistochemistry with antibodies against CD117 and CD34 was reliable and valuable for diagnosis of EGISTs [7].…”

Section: Discussionmentioning

confidence: 97%

Extragastrointestinal stromal tumor in a kidney transplant recipient

Cai

et al. 2011

Clin Exp Nephrol

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The occurrence of de novo malignant neoplasms has been shown in post-transplant recipients receiving immunosuppressive treatment. We present a case of a rare extragastrointestinal stromal tumor (EGIST) located in the pelvic cavity of a kidney transplant patient. A 57-year-old female patient was admitted to our department because of non-specific lower abdominal pain 6 months after renal transplantation. An abdominal computed tomography scan showed a 4.5 cm diameter pelvic tumor mass. The tumor was resected en bloc and confirmed as not being connected to the gastrointestinal wall. Microscopically, the tumor consisted of typical spindle cells with 2-3 mitotic figures per 50 high-power fields. Immunohistochemically, the tumor cells were strongly positive for CD117 (c-kit), and negative for CD34, SMA, s-100 protein, and desmin. Genetically, the tumor showed a silent mutation in exon 18 of the PDGFRA gene at codon 824 GTC > GTT (V824V) [rs2228230]. No recurrence was noted 24 months after the operation. This case draws our attention to the importance of considering EGISTs (including GISTs), even though they are extremely uncommon, in the differential diagnosis of mesenchymal neoplasms, especially in transplant patients.

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Section: Discussionmentioning

confidence: 97%

Extragastrointestinal stromal tumor in a kidney transplant recipient

Cai

et al. 2011

Clin Exp Nephrol

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“…To our knowledge, only 5 cases have been reported in English literature [12–16]. Pasku et al [15] reported a case of bilateral gluteal and lung metastases in a 56-year-old female with a GIST of the pelvis, initially misdiagnosed as a uterine leiomyosarcoma. She was treated with total resection of the tumor and adjuvant imatinib.…”

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Metastasis of a GIST: A Case Report and Review of the Literature

Savvidou

Chloros

Agrogiannis³

et al. 2016

Case Reports in Surgery

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“…GISTs typically occur in patients over the age of 40 6. Approximately, 10–30% of these neoplasms are asymptomatic and are found incidentally 4.…”

Section: Discussionmentioning

confidence: 99%

A gastrointestinal stromal tumour with pulmonary metastases mimicking unilateral gynaecomastia

2013

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SUMMARYGastrointestinal stromal tumours (GISTs) represent 1% of primary gastrointestinal cancers. These neoplasms most frequently metastasise to the liver and peritoneum and rarely to the lungs and bones. Treatment of unresectable GISTs involves systemic chemotherapy with tyrosine kinase inhibitors, imatinib and sunitinib being first-line and second-line drugs. We report the case of a 52-year-old man with GIST who developed a right-sided subareolar breast swelling and subsequently discovered to be an invasive metastatic pulmonary GIST. Given that gynaecomastia is a known adverse effect of imatinib and sunitinib, this case report illustrates the importance of including metastatic disease in the differential diagnosis of patients with GIST and with the new onset of soft tissue masses. BACKGROUND

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Bilateral gluteal metastases from a misdiagnosed intrapelvic gastrointestinal stromal tumor

Abstract: Background: The location of gastrointestinal stromal tumors (GIST) outside of the gastrointestinal system is a rare event.

Cited by 16 publications

References 18 publications

Extragastrointestinal stromal tumor in a kidney transplant recipient

Extragastrointestinal stromal tumor in a kidney transplant recipient

Skeletal Muscle Metastasis of a GIST: A Case Report and Review of the Literature

A gastrointestinal stromal tumour with pulmonary metastases mimicking unilateral gynaecomastia

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