Bilateral Infiltrative Optic Neuropathy of Systemic Mantle Cell Lymphoma

Aldrees, Sultan; Jeeva-Patel, Trishal; Margolin, Edward

doi:10.1017/cjn.2020.28

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…Prior cases reported treatment with central nervous system penetrating chemotherapy, intravitreal methotrexate and whole brain radiotherapy. 3 , 8 Our patients demonstrated a significant response to high dose intravenous steroids, resulting in an improvement in one patient back to normal visual acuity without dyschromatopsia or a visual field defect. Both patients received further treatment for their leptomeningeal mantle cell lymphoma in addition to the solumedrol, however, the steroids provided the most significant benefit with respect to improvement of visual function.…”

Section: Discussionmentioning

confidence: 68%

“…However once the CNS is involved, the disease has an extremely poor prognosis with a median survival of approximately 5 months. 1 , 3 Up to one quarter of individuals with nervous system involvement will have concomitant ophthalmic disease. 4 Mantle cell lymphoma involving the ocular adnexa occurs in 1–4% of people and is more common in patients with disseminated disease.…”

Section: Introductionmentioning

confidence: 99%

“… 5 , 6 Intraocular involvement has only been reported in 10 prior cases and has a propensity for uveal tissue presumably due to its rich vascular supply. 3 , 4 , 7 Even less common is infiltration of the optic nerve, with only 3 prior reported cases in the literature. 3 , 7 , 8 We present two cases of optic nerve infiltration with mantle cell lymphoma as the first sign of central nervous system involvement of the malignancy.…”

Section: Introductionmentioning

confidence: 99%

“… 3 , 4 , 7 Even less common is infiltration of the optic nerve, with only 3 prior reported cases in the literature. 3 , 7 , 8 We present two cases of optic nerve infiltration with mantle cell lymphoma as the first sign of central nervous system involvement of the malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral vision loss as the initial presentation for central nervous system involvement of mantle cell lymphoma: A case series

Small

Shah

et al. 2021

American Journal of Ophthalmology Case Reports

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Purpose Mantle cell lymphoma is a rare aggressive subtype of non-Hodgkins B cell lymphoma. It typically presents with asymptomatic monoclonal lymphocytosis, lymphadenopathy or bulky extranodal disease. Mantle cell lymphoma rarely affects the central nervous system. We present two cases in which vision loss was the initial symptom of central nervous system involvement by the malignancy. Observations Both patients initially received high dose intravenous steroids with notable improvement in their vision. Conclusions and importance Early detection and management of optic nerve infiltration by mantle cell lymphoma is essential as it improves visual outcomes and enables prompt management of the patient's systemic disease.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bilateral vision loss as the initial presentation for central nervous system involvement of mantle cell lymphoma: A case series

Small

Shah

et al. 2021

American Journal of Ophthalmology Case Reports

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“…We also summarized 48 patients with MCL in the literature who presented with ocular adnexal lesions in order to elucidate their clinical features. 33 - 77 …”

Section: Introductionmentioning

confidence: 99%

Bilateral Lacrimal Gland Mantle Cell Lymphoma in 11-Year Follow-Up: Case Report and Review of 48 Cases With Ocular Adnexal Presentation in the Literature

Matsuo

Tanaka

Okada

et al. 2023

Journal of Investigative Medicine High Impact Case Reports

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A 63-year-old woman, with 11-year history of breast cancer, showed bilateral lacrimal gland enlargement on magnetic resonance imaging. Gallium-67 scintigraphy, as the standard at that time in 2004, demonstrated abnormally high uptake only in bilateral lacrimal glands. The lacrimal glands were extirpated and the pathological diagnosis was mantle cell lymphoma (MCL). She underwent bilateral orbital radiation, based on no uptake of gallium-67 in other sites of the body. In a month, bone marrow biopsy revealed the infiltration with MCL, positive for cyclin D1. She showed hepatic lymphadenopathy and splenomegaly, and so received 2 cycles of alternating Hyper-CVAD therapy and high-dose methotrexate with cytarabine, combined with rituximab, in 2 months, leading to complete remission. She underwent autologous peripheral blood stem cell transplantation and was well until the age of 68 years when she showed a recurrent intratracheal submucosal lesion of lymphoma and underwent one course of reduced-dose CHOP combined with rituximab. Next year, the left rib resection revealed the metastasis of breast adenocarcinoma, leading to daily oral letrozole. Further 2 years later, computed tomographic scan demonstrated multiple submucosal nodular lesions in the trachea and bronchi, together with cervical and supraclavicular lymphadenopathy, and intratracheal lesion biopsy and bone marrow biopsy proved the involvement with MCL. She underwent 2 courses of bendamustine and rituximab, resulting in complete remission but died of metastatic breast cancer at the age of 74 years. Clinical features in 48 previous cases with ocular adnexal MCL in the literature were summarized in this study.

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