Bilateral low-energy sequential femoral shaft fractures in patients on long-term bisphosphonate therapy

Çakmak, Selami; Mahiroğulları, Mahir; Keklikçi, Kenan; Sarı, Enes; Erdik, Baran; Rodop, Osman

doi:10.3944/aott.2013.2934

Cited by 12 publications

(6 citation statements)

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“…These fractures are often seen as a single fracture, and more rarely, bilaterally. These cases are usually present with a fracture in the opposite extremity followed by a recurrent admission (2)(3)(4)(5). In our case, bilateral fracture was present at the time of admission.…”

Section: Discussionmentioning

confidence: 55%

“…More rarely, bilateral femoral fractures occurred at different times have also been observed. (2,5). We present a concurrent, bilateral atypical femur fracture in a postmenopausal female patient using long-term alendronate.…”

Section: Introductionmentioning

confidence: 98%

“…When current literature is reviewed, case reports or case series about atypical femur fractures associated with long-term use of bisphosphonates have been reported (2)(3)(4)(5). More rarely, bilateral femoral fractures occurred at different times have also been observed.…”

Section: Introductionmentioning

confidence: 99%

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Concurrent Bilateral Subtrochanteric Femoral Fracture Related with Long-Term Biphosphonate Usage

Öztürk

Atalay

Özanlağan³

et al. 2020

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Bifosfonatlar osteoporoz tedavisinde yaygın olarak kulanılmaktadır. Bifosfonatların etki mekanizması, kemik rezorpsiyonu supresyonudur. Uzun dönem bifosfonat kullanımında ise son yıllarda gittikçe artan sayıda atipik femur kırıkları bildirilmektedir. Biz, 60 yaşında, metastatik meme karsinomu tanılı, uzun süreli bifosfonat kullanımına bağlı eşzamanlı bilateral femur subtrokanterik kırık ile başvuran postmenapozal kadın hastada, klinik presentasyon, tanı konulması, tedavi ve takibini yayınlıyoruz. Her iki kırık hattından frozen gönderildi, frozen inceleme sonucunda, tümöral dokuya rastlanmadı. Hastanın aynı seansta sağ kalçasına proksimal femoral çivi, sol kalçasına femur proksimal anatomik plak uygulandı. Her iki alt ekstremitesine tam yük vererek yürüyebildiği, kalça eklem hareketlerinde istirahat ve egzersizle ağrı olmadığı görüldü.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 98%

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Concurrent Bilateral Subtrochanteric Femoral Fracture Related with Long-Term Biphosphonate Usage

Öztürk

Atalay

Özanlağan³

et al. 2020

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“…Long-term BMA therapy is expected to prevent the pain caused by bone metastasis. Cakmak recommended radiographic evaluation of both femurs during long-term BMA treatment lasting over five years 12 ) . However, at present, AFF is not well recognized as a complication of long-term BMA use, except in the field of orthopedics.…”

Section: Discussionmentioning

confidence: 99%

Two cases of atypical femoral fracture in cancer patients administered with bone-modifying agents

et al. 2021

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Objective: We report two cases of atypical femoral fracture (AFF) in patients with cancer. Patients: Two patients, a 53-year-old woman with breast cancer and a 77-year-old man with prostate cancer, could not walk after being injured in a fall. They used bone-modifying agents (BMA) for the prevention of bone metastasis for three and four years, respectively. Results: Intramedullary nails were placed to fix the femoral fractures in each patient. Neither of them had pathological metastatic femoral fractures based on fracture site specimens; however, severe suppression of bone turnover at the fracture site was suspected. Both patients could ambulate with a T-cane and were free of hip pain after surgery. Radiographs showed no callus formation at the fracture site. Conclusion: Based on the two cases of AFF in patients with cancer related to BMA use, we should consider that the incidence of AFF may be associated with long-term BMA use.

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“…Some authors have reported an association between alendronic acid and femoral shaft fractures [14,15]. However data regarding ibandronate is limited.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Atypical Femoral Shaft Fractures and Bisphosphonate Therapy; A Case Report

Morrissey¹,

Memon²,

Glynn³

2017

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Bilateral low-energy sequential femoral shaft fractures in patients on long-term bisphosphonate therapy

Cited by 12 publications

References 50 publications

Concurrent Bilateral Subtrochanteric Femoral Fracture Related with Long-Term Biphosphonate Usage

Concurrent Bilateral Subtrochanteric Femoral Fracture Related with Long-Term Biphosphonate Usage

Two cases of atypical femoral fracture in cancer patients administered with bone-modifying agents

Bilateral Atypical Femoral Shaft Fractures and Bisphosphonate Therapy; A Case Report

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