Bilateral Macular Infarction Due to Diaminodiphenyl Sulfone (4.4′ Dds) Toxicity

Chakrabarti, Meena; Suresh, Ponuswamy; Namperumalsamy, P

doi:10.1097/00006982-199901000-00017

Cited by 7 publications

(4 citation statements)

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“…Previous ocular adverse reactions to dapsone have result in retinal necrosis, optic nerve atrophy, and maculopathy [ 3 – 5 , 9 ]. It has been hypothesized that the ocular side effects of dapsone are not due to direct toxicity of the drug, but rather due to ischemia from two distinct mechanisms whose combined effects result in visual changes.…”

Section: Discussionmentioning

confidence: 99%

“…This obstruction is then exacerbated by dapsone-induced methemoglobinemia. The methemoglobinemia lowers the oxygen-carrying capacity of the blood and diminishes the functionality of the remaining hemoglobin, leading to tissue hypoxia and injury [ 3 – 6 , 9 ]. Exudative retinal detachments can be caused by any disruption of the outer blood-retinal barrier.…”

Section: Discussionmentioning

confidence: 99%

“…Ocular side effects of dapsone are uncommon and are often associated with dapsone overdose, though toxicity at therapeutic levels has also been reported. Ocular manifestations of toxicity include retinal necrosis, optic atrophy, and macular infarction [ 3 – 6 ]. To our knowledge, extensive literature search shows no previous reports of bilateral choroidal effusions or retinal detachments associated with dapsone use.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral exudative retinal detachments and associated choroidal detachments in a patient on dapsone: a case report

Dugan

Demirci

2022

Int J Retin Vitr

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Background Dapsone is a synthetic sulfonamide used to treat numerous dermatologic conditions. Ocular side effects have been rarely reported and include retinal necrosis, optic atrophy, and macular infarction. We report the first known case of bilateral choroidal effusions and exudative retinal detachments associated with dapsone use. Case presentation A 57-year-old male with a past medical history of testicular seminoma presented with bilateral blurry vision for 2 months. His exam revealed bilateral choroidal effusions with bilateral exudative retinal detachments without evidence of intraocular tumor. The patient had recently been prescribed dapsone for urticarial vasculitis. The patient was instructed to discontinue dapsone and follow-up closely. Interval follow-up of 8 months demonstrated almost complete resolution of the choroidal effusions and retinal detachments with residual pigment epithelium changes after cessation of dapsone. The patient recovered his pre-detachment visual function. Conclusions Patients on dapsone who present with new visual complaints should undergo a thorough ophthalmic evaluation given the multiple mechanisms by which dapsone can affect the eye.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bilateral exudative retinal detachments and associated choroidal detachments in a patient on dapsone: a case report

Dugan

Demirci

2022

Int J Retin Vitr

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“…However, there are a few reports of dapsone-induced optic neuritis, optic atrophy (OA) and retinal necrosis. There are six case reports of OA following dapsone overdose [3][4][5][6][7][8][9] and one following therapeutic dose. 10 In cases of dapsone overdose, OA was acute in onset, occurring within 1 to 2 weeks.…”

Section: Introductionmentioning

confidence: 99%

Dapsone-induced optic atrophy: a rare case report

Shrestha¹,

Chaudhary²,

Giri³

et al. 2020

LEPROSY

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Dapsone-induced optic atrophy (OA) is very rare at therapeutic doses. A 43-year-old gentleman on WHO-recommended multibacillary Multi-Drug Therapy (WHO MB-MDT) containing rifampicin, dapsone, and clofazimine, presented with bilateral gradual painless diminution of vision after 3 months of medication. He denied any history of trauma, headache, limb weakness, ataxia, diplopia, temporal pain , or weight loss. There was no history of sudden diminution of vision in family members. Fundus examination showed bilateral pale optic discs with well-defined margins. Glucose-6-phosphate dehydrogenase (G6PD) was normal. He was diagnosed with OA secondary to dapsone. There is therefore a possibility of dapsone induced OA even at the therapeutic dose. Hence, we should perform routine eye check-up before starting dapsone.

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Drug-induced ocular side effects

2015

Drug-Induced Ocular Side Effects

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Bilateral Macular Infarction Due to Diaminodiphenyl Sulfone (4.4′ Dds) Toxicity

Cited by 7 publications

References 0 publications

Bilateral exudative retinal detachments and associated choroidal detachments in a patient on dapsone: a case report

Bilateral exudative retinal detachments and associated choroidal detachments in a patient on dapsone: a case report

Dapsone-induced optic atrophy: a rare case report

Drug-induced ocular side effects

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