Bilateral Metachronous Testicular Germ Cell Tumors Occurring in Two Non-Twin Brothers

Kuczyk, Markus A.; Bokemeyer, Carsten; Djamilian, Mohamed; Thon, W. F.; Höfner, K.; Jonas, Udo

doi:10.1159/000282747

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, reports of more than two family members having GCT 7,10,24 as well as reports of the coincidence of famil-the results of the current study agree only in part with the results of the study by Nicholson and Harland. 6 A ial and bilateral GCT, 7,25 and associations of GCT with several urogenital developmental anomalies have conflicting result was reported in a recent study from Denmark, 11 in which no age difference was found be-been reported. 8,26,27 Epidemiologic evidence comes from racial differences in the incidence of GCT 28 and tween FTC cases and sporadic cases, not even in separate analysis of the different histologies.…”

Section: Proportions Of Familial Testicular Cancermentioning

confidence: 94%

The prevalence of familial testicular cancer

Dieckmann

Pichlmeier

1997

Cancer

View full text Add to dashboard Cite

show abstract

Section: Proportions Of Familial Testicular Cancermentioning

confidence: 94%

The prevalence of familial testicular cancer

Dieckmann

Pichlmeier

1997

Cancer

View full text Add to dashboard Cite

show abstract

“…Some data suggest that the relative familial risk of TGCTs is higher for most other types of cancers (for review, see 46). There are numerous reports on families with at least two brothers affected by testicular cancer (7, 8, 47, 48), some reporting on bilateral cases (49). Accordingly, a study reported a higher incidence of bilateral cases vs unilateral in familial cases in comparison with sporadic (6); however, the TGCTs of the two brothers in the present study were both unilateral.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic and molecular analysis of a family with three brothers afflicted with germ‐cell cancer

Ottesen¹,

Meyts²,

Holm³

et al. 2003

Clinical Genetics

View full text Add to dashboard Cite

A thorough cytogenetic investigation and an analysis of detailed questionnaires were performed in a family with three brothers afflicted with germ-cell tumors (GCTs), in an attempt to detect a congenital factor related either to a hereditary genetic background or an environmental/lifestyle influence. One brother had an intracranial tumor in the pineal region and the two others had testicular tumors. Peripheral blood was studied by traditional karyotyping, multicolor-FISH, high-resolution comparative genomic hybridization (HR-CGH), and molecular analysis of selected loci on sex chromosomes (Yq11 region, TSPY, and the androgen receptor gene); however, no abnormalities were detected. The HR-CGH analysis of microdissected histological components of the overt tumors and the adjacent carcinoma in situ demonstrated a pattern of genomic imbalances characteristic for sporadic GCTs, including gain of 12p. The questionnaire and interview revealed a history of different cancers in the extended family, and a possible in utero and/or infantile exposure of the three brothers with GCTs to compounds suspected of endocrine-disrupting properties. Although no genetic aberration was detected in this family, we suspect the presence of a recessive hereditary factor pre-disposing to cancer, which probably was manifested as GCTs in the three brothers because of an adverse effect of an environmental factor on the early germ-cell differentiation.

show abstract