Bilateral middle ear cholesterol granuloma in familial hypercholesterolemia

Masaany, M; Siti, Hashim Sabzah; Idris, Nurliza; Ami, Mazita

doi:10.1016/j.otohns.2008.02.020

Cited by 12 publications

(7 citation statements)

References 4 publications

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“…Based on the current Malaysian total population of 32 million and the prevalence of 1:100, it was estimated that there were approximately 320,000 of individuals with Potential FH in Malaysia. Assuming that all FH cases in Malaysia were reported [36][37][38][39][40][41][42][43] , and taking 1:500 global prevalence of FH, this translates to an estimated detection rate of 2.3% and 0.3% for all categories of FH and potential FH respectively.…”

Section: Resultsmentioning

confidence: 99%

Familial Hypercholesterolaemia in the Malaysian Community: Prevalence, Under-Detection and Under-Treatment

Chua

Razman

Ramli

et al. 2021

JAT

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Aim: Familial hypercholesterolaemia (FH) is the most common autosomal dominant lipid disorder, leading to severe hypercholesterolaemia. Early detection and treatment with lipid-lowering medications may reduce the risk of premature coronary artery disease in FH patients. However, there is scarcity of data on FH prevalence, detection rate, treatment and control with lipid-lowering therapy in the Malaysian community. Methods: Community participants ( n =5130) were recruited from all states in Malaysia. Blood samples were collected for lipid profiles and glucose analyses. Personal and family medical histories were collected by means of assisted questionnaire. Physical examination for tendon xanthomata and premature corneal arcus were conducted on-site. FH were clinically screened using Dutch Lipid Clinic Network Criteria. Results: Out of 5130 recruited community participants, 55 patients were clinically categorised as potential (Definite and Probable) FH, making the prevalence FH among the community as 1:100. Based on current total population of Malaysia (32 million), the estimated number of FH patients in Malaysia is 320,000, while the detection rates are estimated as 0.5%. Lipid-lowering medications were prescribed to 54.5% and 30.5% of potential and possible FH patients, respectively, but none of them achieved the therapeutic LDL-c target. Conclusion: Clinically diagnosed FH prevalence in Malaysian population is much higher than most of the populations in the world. At community level, FH patients are clinically under-detected, with majority of them not achieving target LDL-c level for high-risk patients. Therefore, public health measures are warranted for early detection and treatment, to enhance opportunities for premature CAD prevention.

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Section: Resultsmentioning

confidence: 99%

Familial Hypercholesterolaemia in the Malaysian Community: Prevalence, Under-Detection and Under-Treatment

Chua

Razman

Ramli

et al. 2021

JAT

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“…All three of these patients had familial hypercholesterolemia and were managed surgically. The second and third cases underwent coronary artery bypass graft surgery at an early age before resection of cholesterol granuloma [5,6]. There should be a high level of suspicion for cholesterol granuloma in patients with familial hypercholesterolemia if they present with temporal bone or intracranial masses.…”

Section: Discussionmentioning

confidence: 99%

Familial hypercholesterolemia with bilateral cholesterol granuloma: A case series

Albakheet

Alshawi

Bafaqeeh³

et al. 2019

International Journal of Surgery Case Reports

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“…Due to its rarity, however, cholesterol granuloma was not included in the differential diagnosis and its destructive pattern might not be expected preoperatively. We reviewed four other case reports, in which cholesterol granuloma was not included in the differential diagnosis until MRI or surgery was performed [8][9][10][11].…”

Section: Discussionmentioning

confidence: 99%

A Large Mastoid Cholesterol Granuloma Eroding the Dura and Sigmoid Sinus

Hsieh¹

2014

J Cytol Histol

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Introduction: Large mastoid cholesterol granulomas, particularly aggressive ones, are rare. We present the first case of a mastoid cholesterol granuloma with a nonspecific clinical presentation, and aggressive behavior, destroying the petrous internal cortical plate, dura mater, and sigmoid sinus wall. Radiographic and histological examinations can help to distinguish such granulomas from others.Case presentation: A 50-year-old male presented with left otalgia, left blood-stained otorrhea, and a left temporal headache radiating to the mastoid. The radiographic examination revealed a left-sided, soft-tissue mass extending into the posterior fossa and compressing the sigmoid sinus inward. The histopathological features were consistent with a cholesterol granuloma. He underwent a cortical mastoidectomy to explore the lesion and macroscopic complete resection was achieved. Conclusion:This is the first case of a mastoid cholesterol granuloma eroding the dura and sigmoid sinus. This case illustrates the need to consider cholesterol granuloma in daily clinical practice. Such lesions can exhibit non-characteristic features and have an aggressive nature.

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Bilateral middle ear cholesterol granuloma in familial hypercholesterolemia

Cited by 12 publications

References 4 publications

Familial Hypercholesterolaemia in the Malaysian Community: Prevalence, Under-Detection and Under-Treatment

Familial Hypercholesterolaemia in the Malaysian Community: Prevalence, Under-Detection and Under-Treatment

Familial hypercholesterolemia with bilateral cholesterol granuloma: A case series

A Large Mastoid Cholesterol Granuloma Eroding the Dura and Sigmoid Sinus

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