Bilateral Odontogenic Keratocyst of the Mandible

Ram, Hari; Mohammad, Shadab; Husain, Nuzhat; Gupta, Shalini; Kumar, Ajay

doi:10.1007/s12663-010-0109-5

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…2C) 19 . The caseous material accumulates as the keratinized stratified squamous epithelium lining sloughs into the cyst lumen 20 . These lesions are notorious for recurrence due to the crypts they form in the involved bone, and they have been known to invade adjacent soft tissues and even the skull base 21,22 .…”

Section: Discussionmentioning

confidence: 99%

“…19 The caseous material accumulates as the keratinized stratified squamous epithelium lining sloughs into the cyst lumen. 20 These lesions are notorious for recurrence due to the crypts they form in the involved bone, and they have been known to invade adjacent soft tissues and even the skull base. 21,22 A systematic review of OKC management demonstrated a 17% to 56% recurrence rate with enucleation alone, whereas the addition of Carnoy's solution or decompression before enucleation lowered the recurrence rate to 1% to 8.7%.…”

Section: Odontogenic Keratocystmentioning

confidence: 99%

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Pediatric Odontogenic and Maxillofacial Bone Pathology: A Global Analysis

Garg

O'Connor

Sterling

et al. 2021

Journal of Craniofacial Surgery

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Background: Although pathology in the maxillary and mandibular bones is rare in young patients, the differential diagnosis is broad. The World Health Organization (WHO) updated its classification of maxillofacial bone pathology in 2017. Using these updated guidelines, a systematic review of common maxillofacial bone lesions in the pediatric population was performed. Methods: A PubMed search was conducted capturing English language articles from inception to July 2020. Thirty-one articles were identified that described the frequency of maxillofacial bone pathology. Data were extracted and organized using the WHO 2017 classification of odontogenic and maxillofacial bone tumors. Prevalence data were analyzed among diagnostic categories and geographical regions. The SAS version 9.4 was used to complete statistical analyses. Results: The articles included patients from birth to a maximum age of 14 to 19 years. The most common odontogenic cysts included radicular cyst (42.7%) and dentigerous cyst (39.0%) followed by odontogenic keratocyst (15.0%). Among odontogenic bone tumors, odontoma (49.3%) was most common followed by ameloblastoma (29.1%). The most common nonodontogenic bone tumor was fibrous dysplasia (42.4%), and the most common malignant bone tumor was osteosarcoma (75.0%). Significant variations were found by geographic region, with dentigerous cyst more common than radicular cyst, and ameloblastoma more common than odontoma in African and Asian countries (P < 0.0001). Conclusions: This systematic review uses the WHO 2017 guidelines to classify common odontogenic and nonodontogenic maxillofacial bone lesions around the world. Pathogenesis, presentation, and available treatment options for the most common maxillofacial bone lesions are reviewed.

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Section: Discussionmentioning

confidence: 99%

Section: Odontogenic Keratocystmentioning

confidence: 99%

Pediatric Odontogenic and Maxillofacial Bone Pathology: A Global Analysis

Garg

O'Connor

Sterling

et al. 2021

Journal of Craniofacial Surgery

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“…They present as painless swellings. [ 6 ] OKCs are typically seen as a solitary, lucent, unilocular lesion with smooth corticated borders on orthopantomogram (OPG). Literature is scanty on MRI features and includes T1-hypointensity and T2-hyperintensity in keeping with cystic nature of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Delayed diagnosis of Gorlin syndrome: Learning from mistakes!

et al. 2015

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Gorlin syndrome (GS) is a rare inherited multisystem disorder with predisposition to basal cell carcinomas and various other neoplasms. Characteristic features include falx calcification, multiple odontogenic keratocysts (OKCs), early onset medulloblastoma, craniofacial and skeletal malformations, cardiac and ovarian fibroma. We present a case of GS in a 9-year-old girl with recurrent dental infections which was overlooked for 8 years. Diagnosis was finally suggested by the incidental detection of multiple OKCs and ovarian fibromas on follow-up magnetic resonance imaging performed for surveillance of previous operated brain tumor.

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“…The odontogenic keratocyst (OK) is defined as a cyst of odontogenic origin characterized by its parakeratinized stratified squamous epithelial lining with nuclear hyperchromatism in its basal cells organized in a palisade [1]. OK was first described in 1876 and named by Phillipsen in 1956, who associated it with a tendency to recur [2,3]. In the third edition of the WHO classification of head and neck tumors, published in 2005, OK changed its designation from developmental cyst to benign odontogenic neoplasm, replacing its name with keratocystic odontogenic tumor, based mainly on its aggressive behavior, high recurrence, and mutations in the PTCH gene [4].…”

Section: Introductionmentioning

confidence: 99%

In Silico Analysis of Genes Associated with the Pathogenesis of Odontogenic Keratocyst

Ramírez-Martínez,

Legorreta-Villegas,

Mejía-Velázquez

et al. 2024

IJMS

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Odontogenic keratocyst (OK) is a benign intraosseous cystic lesion characterized by a parakeratinized stratified squamous epithelial lining with palisade basal cells. It represents 10–12% of odontogenic cysts. The changes in its classification as a tumor or cyst have increased interest in its pathogenesis. Objective: Identify key genes in the pathogenesis of sporadic OK through in silico analysis. Materials and methods: The GSE38494 technical sheet on OK was analyzed using GEOR2. Their functional and canonical signaling pathways were enriched in the NIH-DAVID bioinformatic platform. The protein–protein interaction network was constructed by STRING and analyzed with Cytoscape-MCODE software v 3.8.2 (score > 4). Post-enrichment analysis was performed by Cytoscape-ClueGO. Results: A total of 768 differentially expressed genes (DEG) with a fold change (FC) greater than 2 and 469 DEG with an FC less than 2 were identified. In the post-enrichment analysis of upregulated genes, significance was observed in criteria related to the organization of the extracellular matrix, collagen fibers, and endodermal differentiation, while the downregulated genes were related to defensive response mechanisms against viruses and interferon-gamma activation. Conclusions. Our in silico analysis showed a significant relationship with mechanisms of extracellular matrix organization, interferon-gamma activation, and response to viral infections, which must be validated through molecular assays.

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Bilateral Odontogenic Keratocyst of the Mandible

Abstract: Odontogenic keratocyst (OKC) is a cyst of dental origin with an aggressive clinical behavior, having high recurrence rate. Multiple cysts are associated with bifid-rib basal cell nevus syndrome (Gorlin syndrome). We present a case of bilateral odontogenic keratocyst in a cleft lip patient.

Cited by 6 publications

References 31 publications

Pediatric Odontogenic and Maxillofacial Bone Pathology: A Global Analysis

Pediatric Odontogenic and Maxillofacial Bone Pathology: A Global Analysis

Delayed diagnosis of Gorlin syndrome: Learning from mistakes!

In Silico Analysis of Genes Associated with the Pathogenesis of Odontogenic Keratocyst

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