Bilateral optic disk edema and blindness as initial presentation of acute lymphocytic leukemia

Mayo, George L.; Carter, John E.; McKinnon, Stuart J.

doi:10.1016/s0002-9394(02)01465-4

Cited by 56 publications

(38 citation statements)

References 5 publications

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“…Our patient had hypercellularity in the CSF perhaps being the reason for her symptoms per se. Several papers have also described different ocular manifestations including papilledema as a consequence of direct infiltration of the optic nerve(s) or indirectly due to increased intracranial pressure in patients with leukemia [1,9,16,19,24,30]. The patients with leukemia involving CNS are usually asymptomatic [27]; however, patients with overt CNS involvement may present diverse symptoms including cranial nerve deficits, seizures, altered mental status and even spinal cord compression as well as increased ICP [23,27], and if CNS symptoms dominate, these cases may easily be misdiagnosed [7].…”

Section: Discussionmentioning

confidence: 99%

An adolescent with suspected intracranial hypertension—ALL is not what it seems

Jakola

Gulati

2012

Childs Nerv Syst

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Section: Discussionmentioning

confidence: 99%

An adolescent with suspected intracranial hypertension—ALL is not what it seems

Jakola

Gulati

2012

Childs Nerv Syst

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“…Infiltration can occur along the optic nerve or the vasculature supplying the orbital structures, resulting in papilloedema [1]. Retinal haemorrhage is the most common finding in leukaemic ophthalmopathy [4]. Other causes of vision loss in patients with leukaemia include vincristine-induced optic atrophy, cortical blindness and radiation retinopathy [5].…”

Section: Discussionmentioning

confidence: 99%

Rapid vision loss in a 15-year-old boy

Mittal

Ko²,

Chang³

2011

BJR

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A 15-year-old boy with a recent diagnosis of T-cell acute lymphoblastic leukaemia (ALL) and a history of factor V Leiden heterozygosity presented with a sudden onset of bilateral vision loss over a 24 h period. 2 weeks prior to presentation he received pegaspargase chemotherapy. During the week preceding admission he had noted mild blurred vision and complained of retro-orbital headaches. Ophthalmic examination revealed visual acuity of 20/800 in the right eye and minimal light perception in the left eye. He had sluggish pupillary reactivity to light with a left relative afferent pupillary defect. Dilated fundoscopic examination demonstrated bilateral florid optic disc swelling with peripapillary and dot-blot haemorrhages in the periphery, and macular oedema of the left eye. Neurological examination demonstrated mild left peripheral seventh nerve palsy.Multiplanar and multisequence MRI of the orbits, face and neck were obtained before and after administration of 20 cc iv contrast (Figures 1-4).

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“…Embora na fase aguda possa ocorrer edema do DO na maioria destas neuropatias, (53)(54)(55)(56) a sua característi-ca principal é a do desenvolvimento progressivo de perda da CFNR que pode ser identificada e quantificada seja pela polarimetria com laser de varredura seja pela TCO.…”

Section: Neuropatias Compressivasunclassified

Avaliação da camada de fibras nervosas da retina nas afecções neuroftalmológicas da via óptica anterior

Monteiro¹

2012

Rev. bras.oftalmol.

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Avaliação da camada de fibras nervosas da retina nas afecções neuroftalmológicas da via óptica anterior Retinal nerve fiber evaluation in neuro-ophthalmic diseases of the anterior visual pathwayMário Luiz Ribeiro Monteiro* RESUMOA avaliação da camada de fibras nervosas da retina tem grande importância no diagnóstico e acompanhamento de várias afecções da via óptica anterior. Nesta revisão, discutiremos os principais métodos de análise clínica e instrumental da camada de fibras nervosas da retina e revisamos os principais achados encontrados nas afecções da via óptica anterior incluindo lesões inflamatórias, isquêmicas, tóxicas, hereditárias, compressivas e traumáticas do nervo óptico, as lesões do quiasma óptico, as do trato óptico e aquelas do corpo geniculado lateral.Descritores: Camada de fibras nervosas da retina; Neuropatias ópticas; Quiasma; Trato óptico; Corpo geniculado lateral; Tomografia de coerência óptica ABSTRACTRetinal nerve fiber evaluation is important in the diagnosis and management of several diseases of the anterior visual pathway. In this report we review the clinical findings and the current techonologies avalilable to analyse the retinal nerve fiber layer. We furthermore review the main findings in several disease of the anterior visual pathways including inflammatory, ischemic, toxics, hereditary, compressive and traumatic optic neuropathies as well as lesion of the optic chiasm, optic tract and lateral geniculate body.

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Bilateral optic disk edema and blindness as initial presentation of acute lymphocytic leukemia

Cited by 56 publications

References 5 publications

An adolescent with suspected intracranial hypertension—ALL is not what it seems

An adolescent with suspected intracranial hypertension—ALL is not what it seems

Rapid vision loss in a 15-year-old boy

Avaliação da camada de fibras nervosas da retina nas afecções neuroftalmológicas da via óptica anterior

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