Bilateral orbital metastases from breast carcinoma

Toller, Kevin K; Gigantelli, James W.; Spalding, Marianne

doi:10.1016/s0161-6420(98)91037-5

Cited by 48 publications

(44 citation statements)

References 38 publications

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“…Metastastic carcinoma to the extraocular muscles is extremely rare [1,7], accounting for 9% of all metastases to the orbit [11]. Only 4 cases of bilateral orbital metastases affecting all the extraocular muscles, as in our patient, have been reported [5][6][7]11]. The first case report was that of Bedford et al [7] (table 1).…”

Section: Discussionmentioning

confidence: 68%

“…The commonest one is breast carcinoma, accounting for 10-61% [5,6]. Metastatic carcinoma to the ocular muscles is extremely rare [1,2,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Metastatic carcinoma to the ocular muscles is extremely rare [1,2,6,7]. The basis for breast cancer as the predominant orbital metastatic neoplasm lacks adequate explanation to date Bilateral Metastases to Extraocular Muscles from Lobular Breast Carcinoma [5]. It may be attributed to the fact that the muscles are in a more or less constant state of movement, thus preventing the lodgment of neoplastic cells or producing an unsuitable chemical environment for their continuous growth [2,5].…”

Section: Introductionmentioning

confidence: 99%

“…The basis for breast cancer as the predominant orbital metastatic neoplasm lacks adequate explanation to date Bilateral Metastases to Extraocular Muscles from Lobular Breast Carcinoma [5]. It may be attributed to the fact that the muscles are in a more or less constant state of movement, thus preventing the lodgment of neoplastic cells or producing an unsuitable chemical environment for their continuous growth [2,5]. Orbital metastases involving extraocular muscles may be associated with extensive meningeal blastomatosis with invasion of craniospinal nerve roots, a condition known to produce various neuroophthalmologic lesions [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…It may be attributed to the fact that the muscles are in a more or less constant state of movement, thus preventing the lodgment of neoplastic cells or producing an unsuitable chemical environment for their continuous growth [2,5]. Orbital metastases involving extraocular muscles may be associated with extensive meningeal blastomatosis with invasion of craniospinal nerve roots, a condition known to produce various neuroophthalmologic lesions [3,5]. We report on a patient with breast cancer who developed bilateral extraocular metastases 5 years post mastectomy, and we also reviewed the literature on this uncommon metastatic location.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral Metastases to Extraocular Muscles from Lobular Breast Carcinoma

et al. 2008

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Background: Metastastic carcinoma to extraocular muscles is extremely rare, but even more so is the case of a bilateral one. Case report: A 50-year-old woman with a history of mastectomy for a T4N1M0 right breast carcinoma was referred to us with diplopia due to bilateral extraocular muscle metastases, 5 years post mastectomy. Multiple metastases to the whole body were also present. A combination of high-dose irradiation, hormonotherapy and chemotherapy were performed. Results: Despite the multidisciplinary treatment approach, the diplopia persisted. A literature review revealed only 4 cases of bilateral metastases to extraocular muscles. The present case is the second attributed to lobular carcinoma and the only one treated with a high dose of radiotherapy combined with systemic therapy. Conclusion: In a cancer patient, any orbital change must be examined for the possibility of an extraocular metastasis. Conclusions affecting the optimal treatment policy of extraocular muscle metastases are difficult to determine, due to the small number of reported cases.

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