Bilateral Orbital Myeloid Sarcoma as Initial Sign of Acute Myeloid Leukemia: Case Report and Review of the Literature

Shields, Jerry A.; Stopyra, Gary A; Marr, Brian P.; Shields, Carol L.; Pan, W S; Eagle, Ralph C.; Bernstein, Jay

doi:10.1001/archopht.121.1.138

Cited by 54 publications

(28 citation statements)

References 31 publications

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“…The conjunctiva is rarely involved. 4 In our patient, the lesion extended into the orbit but was solely in the conjunctiva and did not involve the medial rectus muscle. Among patients with AML, relapses were observed in 63% of patients with ocular or orbital involvement compared with 30.2% of patients without involvement in the aforementioned locations.…”

Section: Discussionmentioning

confidence: 51%

Ocular myeloid sarcoma in a 10-year-old child

Hong

Longmuir

Goins

2011

Journal of American Association for Pediatric Ophthalmology and

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Section: Discussionmentioning

confidence: 51%

Ocular myeloid sarcoma in a 10-year-old child

Hong

Longmuir

Goins

2011

Journal of American Association for Pediatric Ophthalmology and

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“…13,14 Most of the reported cases of orbital or conjunctival MS refer to lesions presenting as the initial manifestation of disease and preceding the recognition of the underlying leukemia. 15 This is, to the authors' knowledge, the second reported case in the English medical literature of an isolated MS in both eyelids as an aleukemic form of leukemia cutis in an adult, and should raise due awareness of the clinical setting at hand combined with the required pathological immunophenotyping.…”

Section: Discussionmentioning

confidence: 72%

Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course

Iliadis

Κoletsa

Georgiou

et al. 2016

The American Journal of Dermatopathology

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Leukemic infiltrates may be seen in the skin in the absence of detectable bone marrow involvement. Leukemia cutis may exceptionally occupy the eyelids. An unusual case of a 58-year-old man presenting bilateral erythematous eyelid lesions, proven to be aleukemic leukemia cutis, is reported. Biopsy was conducted and hematoxylin/eosin stained sections were histologically evaluated. Immunohistochemistry was also performed.Light microscopy revealed cutaneous infiltration by a neoplastic population consisting of medium-sized cells. These cells infiltrated the overlying epidermis leading to focal microulcerations. The morphological and immunohistochemical characteristics of the neoplastic population were compatible with myeloid leukemia cutis. The bone marrow biopsy was normocellular for the patient's age. Although chemotherapy was advised, the patient refused any treatment. He remains free of leukemia or evolution of eyelid lesions approximately 1 year after diagnosis. Leukemia cutis of the eyelids is a rare manifestation of acute leukemia and may remain aleukemic in adults for an indefinite period of time.

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“…GS is seen in certain subtypes of AML, in particular M5a, M5b, M4, and M2 of AML [9]. M4 and M5 subtypes are associated with a poor prognosis [10].…”

Section: Discussionmentioning

confidence: 99%