2004
DOI: 10.1523/jneurosci.1921-04.2004
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Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency

Abstract: The orbital prefrontal cortex (PFo) operates as part of a network involved in reward-based learning and goal-directed behavior. To test whether the PFo is necessary for guiding behavior based on the value of expected reward outcomes, we compared four rhesus monkeys with two-stage bilateral PFo removals and six unoperated controls for their responses to reinforcer devaluation, a task that assesses the monkeys' abilities to alter choices of objects when the value of the underlying food has changed. For compariso… Show more

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Cited by 552 publications
(651 citation statements)
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“…Lesions or temporary inactivations of the rodent prelimbic area do not impair reversal learning of a two-choice discrimination (Birrell & Brown, 2000;Boulougouris, Dalley, & Robbins, 2007;Ragozzino, Detrick, & Kesner, 1999;Ragozzino, Kim, Hassert, Minniti, & Kiang, 2003). However, lesions or pharmacological manipulations of the orbitofrontal region impair reversal learning for olfactory, tactile, or visual cues (Bohn, Giertler, & Hauber, 2003;Boulougouris et al, 2007;Chudasama & Robbins, 2003;Ferry, Lu, & Price, 2000;Izquierdo, Suda, & Murray, 2004;Kim & Ragozzino, 2005;McAlonan & Brown, 2003;Meunier, Bachevalier, & Mishkin, 1997;Rolls, Hornak, Wade, & McGrath, 1994;Schoenbaum et al, 2002aSchoenbaum et al, , 2002b. The orbitofrontal cortex may support reversal learning by governing goal-directed behavior or behavior guided by incentive values associated with a stimulus (Saddoris, Gallagher, & Schoenbaum, 2005;Schoenbaum & Roesch, 2005;Schoenbaum & Setlow, 2001;Schoenbaum, Setlow, Nugent, Saddoris, & Gallagher, 2003a;Schoenbaum, Setlow, & Ramus, 2003b;Schoenbaum, Setlow, Saddoris, & Gallagher, 2003c).…”
Section: Discussionmentioning
confidence: 99%
“…Lesions or temporary inactivations of the rodent prelimbic area do not impair reversal learning of a two-choice discrimination (Birrell & Brown, 2000;Boulougouris, Dalley, & Robbins, 2007;Ragozzino, Detrick, & Kesner, 1999;Ragozzino, Kim, Hassert, Minniti, & Kiang, 2003). However, lesions or pharmacological manipulations of the orbitofrontal region impair reversal learning for olfactory, tactile, or visual cues (Bohn, Giertler, & Hauber, 2003;Boulougouris et al, 2007;Chudasama & Robbins, 2003;Ferry, Lu, & Price, 2000;Izquierdo, Suda, & Murray, 2004;Kim & Ragozzino, 2005;McAlonan & Brown, 2003;Meunier, Bachevalier, & Mishkin, 1997;Rolls, Hornak, Wade, & McGrath, 1994;Schoenbaum et al, 2002aSchoenbaum et al, , 2002b. The orbitofrontal cortex may support reversal learning by governing goal-directed behavior or behavior guided by incentive values associated with a stimulus (Saddoris, Gallagher, & Schoenbaum, 2005;Schoenbaum & Roesch, 2005;Schoenbaum & Setlow, 2001;Schoenbaum, Setlow, Nugent, Saddoris, & Gallagher, 2003a;Schoenbaum, Setlow, & Ramus, 2003b;Schoenbaum, Setlow, Saddoris, & Gallagher, 2003c).…”
Section: Discussionmentioning
confidence: 99%
“…First, rats and monkeys with OFC lesions are not sensitive to devaluation (Gallagher, McMahan, & Schoenbaum, 1999;Izquierdo, Suda, & Murray, 2004;Pickens, Saddoris, Gallagher, & Holland, 2005). In contrast, rats with dorsolateral striatal lesions are more sensitive than control rats (Yin, Knowlton, & Balleine, 2004).…”
Section: Devaluationmentioning
confidence: 94%
“…Although apathy and lack of affect is sometimes reported after to the dorsomedial prefrontal cortex, the nearly opposite symptoms of euphoria, impulsiveness, and general emotional disinhibition may be reported after damage to the ventromedial prefrontal and orbitofrontal cortex (Tucker et al 1995). Similarly, monkeys or rats with damage to orbitofrontal cortex (OFC) still respond robustly for rewards but are disrupted in subtle ways on the cognitive use of reward information to guide behavioral decisions (Burke et al 2008;Izquierdo et al 2004;Pears et al 2003;Pickens et al 2003;Rudebeck et al 2006;Schoenbaum et al 2006;Wallis 2007). As Schoenbaum and Shaham concluded, "the OFC does not appear to play an important role in the acute rewarding effect of cocaine or in relapse induced by acute exposure to the drug.…”
Section: Cortical Causation Of Human Pleasure?mentioning
confidence: 99%